Methods and systems for utilizing diagnostics for informed vibrant constituional guidance

ABSTRACT

A system for utilizing diagnostics for informed vibrant constitutional guidance includes at least a server, a diagnostic engine operating on the at least a server configured to generate a machine learning model trained by a training set, wherein the machine-learning model is configured to receive contextual information as an input and output a diagnostic output wherein the training data set includes a plurality of data entries, each data entry including at least an element of contextual information and at least a correlated diagnostic output, and at least an advisory module, operating on the at least a server configured to generate an advisory output as a function of the diagnostic output, wherein the advisory output comprises textual data identifying the diagnostic output and wherein the textual data identifying the diagnostic output is configured to be displayed on an advisor client device, and transmit the advisory output to the advisor client device.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of Non-provisional application Ser.No. 16/372,512 filed on Apr. 2, 2019 and entitled “METHODS AND SYSTEMSFOR UTILIZING DIAGNOSTICS FOR INFORMED VIBRANT CONSTITUIONAL GUIDANCE,”the entirety of which is incorporated herein by reference.

FIELD OF THE INVENTION

The present invention generally relates to the field of diagnostics. Inparticular, the present invention is directed to methods and systems forutilizing diagnostics for informed vibrant constitutional guidance.

BACKGROUND

Automated analysis of data and correct transmission of said data can bechallenging due to the complexity of and multiplicity of data to beanalyzed. Knowing which data should be transmitted to which skilledprofessional can be highly complex due to the unique and individualneeds of each user—a problem exacerbated by the burgeoning volume ofdata available for analysis. Transmissions to incorrect professionalscan lead to inaccuracies within systems, waste time trying to correctcumbersome issues, and ultimately frustrate users.

SUMMARY OF THE DISCLOSURE

Aspects of the present disclosure are directed to a system for utilizingdiagnostics for informed vibrant constitutional guidance, wherein thesystem includes at least a server, a diagnostic engine operating on theat least a server, wherein the diagnostic engine is configured togenerate a machine learning model, wherein the machine-learning modelcomprises a trained machine-learning model trained by a training dataset, wherein the machine-learning model is configured to receivecontextual information as an input and output a diagnostic output,wherein the training data set includes a plurality of data entries, eachdata entry of the plurality of data entries including at least anelement of contextual information and at least a correlated diagnosticoutput, and at least an advisory module, operating on the at least aserver, the at least an advisory module designed and configured togenerate an advisory output as a function of the diagnostic output,wherein the advisory output comprises textual data identifying thediagnostic output and wherein the textual data identifying thediagnostic output is configured to be displayed on an advisor clientdevice, and transmit the advisory output to the advisor client device.

Aspects of the present disclosure are directed to a method of utilizingdiagnostics for informed vibrant constitutional guidance, wherein themethod includes generating, by a diagnostic engine operating on the atleast a server, a machine-learning model, wherein the machine-learningmodel comprises a trained machine-learning model trained by a trainingdata set, wherein the machine-learning model is configured to receivecontextual information as an input and output a diagnostic output,wherein the training data set includes a plurality of data entries, eachdata entry of the plurality of data entries including at least anelement of contextual information and at least a correlated diagnosticoutput, and generating, by an advisory module operating on at least theserver, an advisory output as a function of the diagnostic output,wherein the advisory output comprises textual data identifying thediagnostic output and wherein the textual data identifying thediagnostic output is configured to be displayed on an advisor clientdevice, and transmitting, by the advisory module operating on at leastthe server, the advisory output to the advisor client device.

BRIEF DESCRIPTION OF THE DRAWINGS

For the purpose of illustrating the invention, the drawings show aspectsof one or more embodiments of the invention. However, it should beunderstood that the present invention is not limited to the precisearrangements and instrumentalities shown in the drawings, wherein:

FIG. 1 is a block diagram illustrating an exemplary embodiment of asystem for utilizing diagnostics for informed vibrant constitutionalguidance;

FIG. 2 is a block diagram illustrating embodiments of data storagefacilities for use in disclosed systems and methods;

FIG. 3 is a block diagram illustrating an exemplary embodiment of abiological extraction database;

FIG. 4 is a block diagram illustrating an exemplary embodiment of anexpert knowledge database;

FIG. 5 is a block diagram illustrating an exemplary embodiment of aprognostic label database;

FIG. 6 is a block diagram illustrating an exemplary embodiment of anameliorative process label database;

FIG. 7 is a block diagram illustrating an exemplary embodiment of aprognostic label learner and associated system elements;

FIG. 8 is a block diagram illustrating an exemplary embodiment of anameliorative process label learner and associated system elements;

FIG. 9 is a block diagram illustrating an exemplary embodiment of a plangenerator module and associated system elements;

FIG. 10 is a block diagram illustrating an exemplary embodiment of aprognostic label classification database;

FIG. 11 is a block diagram illustrating an exemplary embodiment of anameliorative process label classification database;

FIG. 12 is a block diagram illustrating an exemplary embodiment of anarrative language database;

FIG. 13 is a block diagram illustrating an exemplary embodiment of animage database;

FIG. 14 is a block diagram illustrating an exemplary embodiment of auser database;

FIG. 15 is a block diagram illustrating an exemplary embodiment of anadvisory module and associated system elements;

FIG. 16 is a block diagram illustrating an exemplary embodiment of anartificial intelligence advisor and associated system elements;

FIG. 17 is a block diagram illustrating an exemplary embodiment of anadvisory database;

FIG. 18 is a block diagram illustrating an exemplary embodiment of adefault response database;

FIG. 19 is a flow diagram illustrating an exemplary embodiment of amethod of utilizing diagnostics for informed vibrant constitutionalguidance; and

FIG. 20 is a block diagram of a computing system that can be used toimplement any one or more of the methodologies disclosed herein and anyone or more portions thereof.

The drawings are not necessarily to scale and may be illustrated byphantom lines, diagrammatic representations and fragmentary views. Incertain instances, details that are not necessary for an understandingof the embodiments or that render other details difficult to perceivemay have been omitted.

DETAILED DESCRIPTION

At a high level, aspects of the present disclosure are directed tosystems and methods for utilizing diagnostics for informed vibrantconstitutional guidance. In an embodiment, classification of biologicalextractions to one or more prognostic labels is accomplished usingtraining set data. Prognostic labels are further linked to ameliorativeprocess labels using additional training sets. Prognostic andameliorative labels are utilized to generate a diagnostic output.Diagnostic output is then utilized to generate at least an advisoryoutput. Advisory output may then be transmitted to an advisor clientdevice which may be operated by an informed advisor which may include anetwork of functional medicine professionals, spiritual professionals,nutrition professionals, fitness professionals, family and friends,electronic behavior coaches, artificial intelligence advisors, andmiscellaneous advisors.

Turning now to FIG. 1, a system 100 for utilizing diagnostics forinformed vibrant constitutional guidance is illustrated. Turning now toFIG. 1, an artificial intelligence advisory system 100 for vibrantconstitutional guidance. Artificial intelligence advisory systemincludes at least a server 104. At least a server 104 may include anycomputing device as described below in reference to FIG. 19, includingwithout limitation a microcontroller, microprocessor, digital signalprocessor (DSP) and/or system on a chip (SoC) as described below inreference to FIG. 19. At least a server 104 may be housed with, may beincorporated in, or may incorporate one or more sensors of at least asensor. Computing device may include, be included in, and/or communicatewith a mobile device such as a mobile telephone or smartphone. At leasta server 104 may include a single computing device operatingindependently, or may include two or more computing device operating inconcert, in parallel, sequentially or the like; two or more computingdevices may be included together in a single computing device or in twoor more computing devices. At least a server 104 with one or moreadditional devices as described below in further detail via a networkinterface device. Network interface device may be utilized forconnecting a at least a server 104 to one or more of a variety ofnetworks, and one or more devices. Examples of a network interfacedevice include, but are not limited to, a network interface card (e.g.,a mobile network interface card, a LAN card), a modem, and anycombination thereof. Examples of a network include, but are not limitedto, a wide area network (e.g., the Internet, an enterprise network), alocal area network (e.g., a network associated with an office, abuilding, a campus or other relatively small geographic space), atelephone network, a data network associated with a telephone/voiceprovider (e.g., a mobile communications provider data and/or voicenetwork), a direct connection between two computing devices, and anycombinations thereof. A network may employ a wired and/or a wirelessmode of communication. In general, any network topology may be used.Information (e.g., data, software etc.) may be communicated to and/orfrom a computer and/or a computing device. At least a server 104 mayinclude but is not limited to, for example, a at least a server 104 orcluster of computing devices in a first location and a second computingdevice or cluster of computing devices in a second location. At least aserver 104 may include one or more computing devices dedicated to datastorage, security, distribution of traffic for load balancing, and thelike. At least a server 104 may distribute one or more computing tasksas described below across a plurality of computing devices of computingdevice, which may operate in parallel, in series, redundantly, or in anyother manner used for distribution of tasks or memory between computingdevices. At least a server 104 may be implemented using a “sharednothing” architecture in which data is cached at the worker, in anembodiment, this may enable scalability of system 100 and/or computingdevice.

Still referring to FIG. 1, system 100 includes a diagnostic engine 108operating on the at least a server 104, wherein the diagnostic engine108 configured to receive a first training set including a plurality offirst data entries, each first data entry of the plurality of first dataentries including at least an element of physiological state data and atleast a correlated first prognostic label; receive a second training setincluding a plurality of second data entries, each second data entry ofthe plurality of second data entries including at least a secondprognostic label and at least a correlated ameliorative process label;receive at least a biological extraction from a user; and generate adiagnostic output based on the at least a biological extraction, thediagnostic output including at least a prognostic label and at least anameliorative process label using the first training set, the secondtraining set, and the at least a biological extraction. At least aserver 104, diagnostic engine 108, and/or one or more modules operatingthereon may be designed and/or configured to perform any method, methodstep, or sequence of method steps in any embodiment described in thisdisclosure, in any order and with any degree of repetition. Forinstance, at least a server 104 and/or diagnostic engine 108 may beconfigured to perform a single step or sequence repeatedly until adesired or commanded outcome is achieved; repetition of a step or asequence of steps may be performed iteratively and/or recursively usingoutputs of previous repetitions as inputs to subsequent repetitions,aggregating inputs and/or outputs of repetitions to produce an aggregateresult, reduction or decrement of one or more variables such as globalvariables, and/or division of a larger processing task into a set ofiteratively addressed smaller processing tasks. At least a server 104and/or diagnostic engine 108 may perform any step or sequence of stepsas described in this disclosure in parallel, such as simultaneouslyand/or substantially simultaneously performing a step two or more timesusing two or more parallel threads, processor cores, or the like;division of tasks between parallel threads and/or processes may beperformed according to any protocol suitable for division of tasksbetween iterations. Persons skilled in the art, upon reviewing theentirety of this disclosure, will be aware of various ways in whichsteps, sequences of steps, processing tasks, and/or data may besubdivided, shared, or otherwise dealt with using iteration, recursion,and/or parallel processing.

Continuing to refer to FIG. 1, diagnostic engine 108 may be designed andconfigured to receive training data. Training data, as used herein, isdata containing correlation that a machine-learning process may use tomodel relationships between two or more categories of data elements. Forinstance, and without limitation, training data may include a pluralityof data entries, each entry representing a set of data elements thatwere recorded, received, and/or generated together; data elements may becorrelated by shared existence in a given data entry, by proximity in agiven data entry, or the like. Multiple data entries in training datamay evince one or more trends in correlations between categories of dataelements; for instance, and without limitation, a higher value of afirst data element belonging to a first category of data element maytend to correlate to a higher value of a second data element belongingto a second category of data element, indicating a possible proportionalor other mathematical relationship linking values belonging to the twocategories. Multiple categories of data elements may be related intraining data according to various correlations; correlations mayindicate causative and/or predictive links between categories of dataelements, which may be modeled as relationships such as mathematicalrelationships by machine-learning processes as described in furtherdetail below. Training data may be formatted and/or organized bycategories of data elements, for instance by associating data elementswith one or more descriptors corresponding to categories of dataelements. As a non-limiting example, training data may include dataentered in standardized forms by persons or processes, such that entryof a given data element in a given field in a form may be mapped to oneor more descriptors of categories. Elements in training data may belinked to descriptors of categories by tags, tokens, or other dataelements; for instance, and without limitation, training data may beprovided in fixed-length formats, formats linking positions of data tocategories such as comma-separated value (CSV) formats and/orself-describing formats such as extensible markup language (XML),enabling processes or devices to detect categories of data.

Alternatively or additionally, and still referring to FIG. 1, trainingdata may include one or more elements that are not categorized; that is,training data may not be formatted or contain descriptors for someelements of data. Machine-learning algorithms and/or other processes maysort training data according to one or more categorizations using, forinstance, natural language processing algorithms, tokenization,detection of correlated values in raw data and the like; categories maybe generated using correlation and/or other processing algorithms. As anon-limiting example, in a corpus of text, phrases making up a number“n” of compound words, such as nouns modified by other nouns, may beidentified according to a statistically significant prevalence ofn-grams containing such words in a particular order; such an n-gram maybe categorized as an element of language such as a “word” to be trackedsimilarly to single words, generating a new category as a result ofstatistical analysis. Similarly, in a data entry including some textualdata, a person's name and/or a description of a medical condition ortherapy may be identified by reference to a list, dictionary, or othercompendium of terms, permitting ad-hoc categorization bymachine-learning algorithms, and/or automated association of data in thedata entry with descriptors or into a given format. The ability tocategorize data entries automatedly may enable the same training data tobe made applicable for two or more distinct machine-learning algorithmsas described in further detail below.

Still referring to FIG. 1, diagnostic engine 108 may be configured toreceive a first training set 112 including a plurality of first dataentries, each first data entry of the first training set 112 includingat least an element of physiological state data 116 and at least acorrelated first prognostic label 120. At least an element ofphysiological state data 116 may include any data indicative of aperson's physiological state; physiological state may be evaluated withregard to one or more measures of health of a person's body, one or moresystems within a person's body such as a circulatory system, a digestivesystem, a nervous system, or the like, one or more organs within aperson's body, and/or any other subdivision of a person's body usefulfor diagnostic or prognostic purposes. Physiological state data 116 mayinclude, without limitation, hematological data, such as red blood cellcount, which may include a total number of red blood cells in a person'sblood and/or in a blood sample, hemoglobin levels, hematocritrepresenting a percentage of blood in a person and/or sample that iscomposed of red blood cells, mean corpuscular volume, which may be anestimate of the average red blood cell size, mean corpuscularhemoglobin, which may measure average weight of hemoglobin per red bloodcell, mean corpuscular hemoglobin concentration, which may measure anaverage concentration of hemoglobin in red blood cells, platelet count,mean platelet volume which may measure the average size of platelets,red blood cell distribution width, which measures variation in red bloodcell size, absolute neutrophils, which measures the number of neutrophilwhite blood cells, absolute quantities of lymphocytes such as B-cells,T-cells, Natural Killer Cells, and the like, absolute numbers ofmonocytes including macrophage precursors, absolute numbers ofeosinophils, and/or absolute counts of basophils. Physiological statedata 116 may include, without limitation, immune function data such asInterleukine-6 (IL-6), TNF-alpha, systemic inflammatory cytokines, andthe like.

Continuing to refer to FIG. 1, physiological state data 116 may include,without limitation, data describing blood-born lipids, including totalcholesterol levels, high-density lipoprotein (HDL) cholesterol levels,low-density lipoprotein (LDL) cholesterol levels, very low-densitylipoprotein (VLDL) cholesterol levels, levels of triglycerides, and/orany other quantity of any blood-born lipid or lipid-containingsubstance. Physiological state data 116 may include measures of glucosemetabolism such as fasting glucose levels and/or hemoglobin A1-C (HbA1c)levels. Physiological state data 116 may include, without limitation,one or more measures associated with endocrine function, such as withoutlimitation, quantities of dehydroepiandrosterone (DHEAS), DHEA-Sulfate,quantities of cortisol, ratio of DHEAS to cortisol, quantities oftestosterone quantities of estrogen, quantities of growth hormone (GH),insulin-like growth factor 1 (IGF-1), quantities of adipokines such asadiponectin, leptin, and/or ghrelin, quantities of somatostatin,progesterone, or the like. Physiological state data 116 may includemeasures of estimated glomerular filtration rate (eGFR). Physiologicalstate data 116 may include quantities of C-reactive protein, estradiol,ferritin, folate, homocysteine, prostate-specific Ag,thyroid-stimulating hormone, vitamin D, 25 hydroxy, blood urea nitrogen,creatinine, sodium, potassium, chloride, carbon dioxide, uric acid,albumin, globulin, calcium, phosphorus, alkaline phosphatase, alanineamino transferase, aspartate amino transferase, lactate dehydrogenase(LDH), bilirubin, gamma-glutamyl transferase (GGT), iron, and/or totaliron binding capacity (TIBC), or the like. Physiological state data 116may include antinuclear antibody levels. Physiological state data 116may include aluminum levels. Physiological state data 116 may includearsenic levels. Physiological state data 116 may include levels offibrinogen, plasma cystatin C, and/or brain natriuretic peptide.

Continuing to refer to FIG. 1, physiological state data 116 may includemeasures of lung function such as forced expiratory volume, one second(FEV-1) which measures how much air can be exhaled in one secondfollowing a deep inhalation, forced vital capacity (FVC), which measuresthe volume of air that may be contained in the lungs. Physiologicalstate data 116 may include a measurement blood pressure, includingwithout limitation systolic and diastolic blood pressure. Physiologicalstate data 116 may include a measure of waist circumference.Physiological state data 116 may include body mass index (BMI).Physiological state data 116 may include one or more measures of bonemass and/or density such as dual-energy x-ray absorptiometry.Physiological state data 116 may include one or more measures of musclemass. Physiological state data 116 may include one or more measures ofphysical capability such as without limitation measures of gripstrength, evaluations of standing balance, evaluations of gait speed,pegboard tests, timed up and go tests, and/or chair rising tests.

Still viewing FIG. 1, physiological state data 116 may include one ormore measures of cognitive function, including without limitation Reyauditory verbal learning test results, California verbal learning testresults, NIH toolbox picture sequence memory test, Digital symbol codingevaluations, and/or Verbal fluency evaluations. Physiological state data204 may include one or more measures of psychological function or state,such as without limitation clinical interviews, assessments ofintellectual functioning and/or intelligence quotient (IQ) tests,personality assessments, and/or behavioral assessments. Physiologicalstate data 204 may include one or more psychological self-assessments,which may include any self-administered and/or automatedlycomputer-administered assessments, whether administered within system100 and/or via a third-party service or platform.

With continued reference to FIG. 1, physiological state data 116 mayinclude one or more evaluations of sensory ability, including measuresof audition, vision, olfaction, gustation, vestibular function and pain.Physiological state data 116 may include genomic data, includingdeoxyribonucleic acid (DNA) samples and/or sequences, such as withoutlimitation DNA sequences contained in one or more chromosomes in humancells. Genomic data may include, without limitation, ribonucleic acid(RNA) samples and/or sequences, such as samples and/or sequences ofmessenger RNA (mRNA) or the like taken from human cells. Genetic datamay include telomere lengths. Genomic data may include epigenetic dataincluding data describing one or more states of methylation of geneticmaterial. Physiological state data 116 may include proteomic data, whichas used herein, is data describing all proteins produced and/or modifiedby an organism, colony of organisms, or system of organisms, and/or asubset thereof. Physiological state data 116 may include data concerninga microbiome of a person, which as used herein, includes any datadescribing any microorganism and/or combination of microorganisms livingon or within a person, including without limitation biomarkers, genomicdata, proteomic data, and/or any other metabolic or biochemical datauseful for analysis of the effect of such microorganisms on otherphysiological state data 116 of a person, and/or on prognostic labelsand/or ameliorative processes as described in further detail below.Physiological state data 116 may include any physiological state data116, as described above, describing any multicellular organism living inor on a person including any parasitic and/or symbiotic organisms livingin or on the persons; non-limiting examples may include mites,nematodes, flatworms, or the like. Examples of physiological state data116 described in this disclosure are presented for illustrative purposesonly and are not meant to be exhaustive. Persons skilled in the art,upon reviewing the entirety of this disclosure, will be aware of variousadditional examples of physiological state data 116 that may be usedconsistently with descriptions of systems and methods as provided inthis disclosure.

Continuing to refer to FIG. 1, each element of first training set 112includes at least a first prognostic label 120. A prognostic label, asdescribed herein, is an element of data identifying and/or describing acurrent, incipient, or probable future medical condition affecting aperson; medical condition may include a particular disease, one or moresymptoms associated with a syndrome, a syndrome, and/or any othermeasure of current or future health and/or heathy aging. At least aprognostic label may be associated with a physical and/or somaticcondition, a mental condition such as a mental illness, neurosis, or thelike, or any other condition affecting human health that may beassociated with one or more elements of physiological state data 116 asdescribed in further detail below. Conditions associated with prognosticlabels may include, without limitation one or more diseases, defined forpurposes herein as conditions that negatively affect structure and/orfunction of part or all of an organism. Conditions associated withprognostic labels may include, without limitation, acute or chronicinfections, including without limitation infections by bacteria,archaea, viruses, viroids, prions, single-celled eukaryotic organismssuch as amoeba, paramecia, trypanosomes, plasmodia, leishmania, and/orfungi, and/or multicellular parasites such as nematodes, arthropods,fungi, or the like. Prognostic labels may be associated with one or moreimmune disorders, including without limitation immunodeficiencies and/orauto-immune conditions. Prognostic labels may be associated with one ormore metabolic disorders. Prognostic labels may be associated with oneor more endocrinal disorders. Prognostic labels may be associated withone or more cardiovascular disorders. Prognostic labels may beassociated with one or more respiratory disorders. Prognostic labels maybe associated with one or more disorders affecting connective tissue.Prognostic labels may be associated with one or more digestivedisorders. Prognostic labels may be associated with one or moreneurological disorders such as neuromuscular disorders, dementia, or thelike. Prognostic labels may be associated with one or more disorders ofthe excretory system, including without limitation nephrologicaldisorders. Prognostic labels may be associated with one or more liverdisorders. Prognostic labels may be associated with one or moredisorders of the bones such as osteoporosis. Prognostic labels may beassociated with one or more disorders affecting joints, such asosteoarthritis, gout, and/or rheumatoid arthritis. Prognostic labels beassociated with one or more cancers, including without limitationcarcinomas, lymphomas, leukemias, germ cell tumor cancers, blastomas,and/or sarcomas. Prognostic labels may include descriptors of latent,dormant, and/or apparent disorders, diseases, and/or conditions.Prognostic labels may include descriptors of conditions for which aperson may have a higher than average probability of development, suchas a condition for which a person may have a “risk factor”; forinstance, a person currently suffering from abdominal obesity may have ahigher than average probability of developing type II diabetes. Theabove-described examples are presented for illustrative purposes onlyand are not intended to be exhaustive. Persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of variousadditional examples of conditions that may be associated with prognosticlabels as described in this disclosure.

Still referring to FIG. 1, at least a prognostic label may be stored inany suitable data and/or data type. For instance, and withoutlimitation, at least a prognostic label may include textual data, suchas numerical, character, and/or string data. Textual data may include astandardized name and/or code for a disease, disorder, or the like;codes may include diagnostic codes and/or diagnosis codes, which mayinclude without limitation codes used in diagnosis classificationsystems such as The International Statistical Classification of Diseasesand Related Health Problems (ICD). In general, there is no limitation onforms textual data or non-textual data used as at least a prognosticlabel may take; persons skilled in the art, upon reviewing the entiretyof this disclosure, will be aware of various forms which may be suitablefor use as at least a prognostic label consistently with thisdisclosure.

With continued reference to FIG. 1, in each first data element of firsttraining set 112, at least a first prognostic label 120 of the dataelement is correlated with at least an element of physiological statedata 116 of the data element. In an embodiment, an element ofphysiological data is correlated with a prognostic label where theelement of physiological data is located in the same data element and/orportion of data element as the prognostic label; for example, andwithout limitation, an element of physiological data is correlated witha prognostic element where both element of physiological data andprognostic element are contained within the same first data element ofthe first training set 112. As a further example, an element ofphysiological data is correlated with a prognostic element where bothshare a category label as described in further detail below, where eachis within a certain distance of the other within an ordered collectionof data in data element, or the like. Still further, an element ofphysiological data may be correlated with a prognostic label where theelement of physiological data and the prognostic label share an origin,such as being data that was collected with regard to a single person orthe like. In an embodiment, a first datum may be more closely correlatedwith a second datum in the same data element than with a third datumcontained in the same data element; for instance, the first element andthe second element may be closer to each other in an ordered set of datathan either is to the third element, the first element and secondelement may be contained in the same subdivision and/or section of datawhile the third element is in a different subdivision and/or section ofdata, or the like. Persons skilled in the art, upon reviewing theentirety of this disclosure, will be aware of various forms and/ordegrees of correlation between physiological data and prognostic labelsthat may exist in first training set 112 and/or first data elementconsistently with this disclosure.

In an embodiment, and still referring to FIG. 1, diagnostic engine 108may be designed and configured to associate at least an element ofphysiological state data 116 with at least a category from a list ofsignificant categories of physiological state data 116. Significantcategories of physiological state data 116 may include labels and/ordescriptors describing types of physiological state data 116 that areidentified as being of high relevance in identifying prognostic labels.As a non-limiting example, one or more categories may identifysignificant categories of physiological state data 116 based on degreeof diagnostic relevance to one or more impactful conditions and/orwithin one or more medical or public health fields. For instance, andwithout limitation, a particular set of biomarkers, test results, and/orbiochemical information may be recognized in a given medical field asuseful for identifying various disease conditions or prognoses within arelevant field. As a non-limiting example, and without limitation,physiological data describing red blood cells, such as red blood cellcount, hemoglobin levels, hematocrit, mean corpuscular volume, meancorpuscular hemoglobin, and/or mean corpuscular hemoglobin concentrationmay be recognized as useful for identifying various conditions such asdehydration, high testosterone, nutrient deficiencies, kidneydysfunction, chronic inflammation, anemia, and/or blood loss. As anadditional example, hemoglobin levels may be useful for identifyingelevated testosterone, poor oxygen deliverability, thiamin deficiency,insulin resistance, anemia, liver disease, hypothyroidism, argininedeficiency, protein deficiency, inflammation, and/or nutrientdeficiencies. In a further non-limiting example, hematocrit may beuseful for identifying dehydration, elevated testosterone, poor oxygendeliverability, thiamin deficiency, insulin resistance, anemia, liverdisease, hypothyroidism, arginine deficiency, protein deficiency,inflammation, and/or nutrient deficiencies. Similarly, measures of lipidlevels in blood, such as total cholesterol, HDL, LDL, VLDL,triglycerides, LDL-C and/or HDL-C may be recognized as useful inidentifying conditions such as poor thyroid function, insulinresistance, blood glucose dysregulation, magnesium deficiency,dehydration, kidney disease, familial hypercholesterolemia, liverdysfunction, oxidative stress, inflammation, malabsorption, anemia,alcohol abuse, diabetes, hypercholesterolemia, coronary artery disease,atherosclerosis, or the like. Persons skilled in the art, upon reviewingthe entirety of this disclosure, will be aware of various additionalcategories of physiological data that may be used consistently with thisdisclosure.

Still referring to FIG. 1, diagnostic engine 108 may receive the list ofsignificant categories according to any suitable process; for instance,and without limitation, diagnostic engine 108 may receive the list ofsignificant categories from at least an expert. In an embodiment,diagnostic engine 108 and/or a user device connected to diagnosticengine 108 may provide a graphical user interface, which may includewithout limitation a form or other graphical element having data entryfields, wherein one or more experts, including without limitationclinical and/or scientific experts, may enter information describing oneor more categories of physiological data that the experts consider to besignificant or useful for detection of conditions; fields in graphicaluser interface may provide options describing previously identifiedcategories, which may include a comprehensive or near-comprehensive listof types of physiological data detectable using known or recordedtesting methods, for instance in “drop-down” lists, where experts may beable to select one or more entries to indicate their usefulness and/orsignificance in the opinion of the experts. Fields may include free-formentry fields such as text-entry fields where an expert may be able totype or otherwise enter text, enabling expert to propose or suggestcategories not currently recorded. Graphical user interface or the likemay include fields corresponding to prognostic labels, where experts mayenter data describing prognostic labels and/or categories of prognosticlabels the experts consider related to entered categories ofphysiological data; for instance, such fields may include drop-downlists or other pre-populated data entry fields listing currentlyrecorded prognostic labels, and which may be comprehensive, permittingeach expert to select a prognostic label and/or a plurality ofprognostic labels the expert believes to be predicted and/or associatedwith each category of physiological data selected by the expert. Fieldsfor entry of prognostic labels and/or categories of prognostic labelsmay include free-form data entry fields such as text entry fields; asdescribed above, examiners may enter data not presented in pre-populateddata fields in the free-form data entry fields. Alternatively oradditionally, fields for entry of prognostic labels may enable an expertto select and/or enter information describing or linked to a category ofprognostic label that the expert considers significant, wheresignificance may indicate likely impact on longevity, mortality, qualityof life, or the like as described in further detail below. Graphicaluser interface may provide an expert with a field in which to indicate areference to a document describing significant categories ofphysiological data, relationships of such categories to prognosticlabels, and/or significant categories of prognostic labels. Any datadescribed above may alternatively or additionally be received fromexperts similarly organized in paper form, which may be captured andentered into data in a similar way, or in a textual form such as aportable document file (PDF) with examiner entries, or the like

Still referring to FIG. 1, diagnostic engine 108 may receive the list ofsignificant categories according to any suitable process; for instance,and without limitation, diagnostic engine 108 may receive the list ofsignificant categories from at least an expert. In an embodiment,diagnostic engine 108 and/or a user device connected to diagnosticengine 108 may provide a graphical user interface 124, which may includewithout limitation a form or other graphical element having data entryfields, wherein one or more experts, including without limitationclinical and/or scientific experts, may enter information describing oneor more categories of physiological data that the experts consider to besignificant or useful for detection of conditions; fields in graphicaluser interface may provide options describing previously identifiedcategories, which may include a comprehensive or near-comprehensive listof types of physiological data detectable using known or recordedtesting methods, for instance in “drop-down” lists, where experts may beable to select one or more entries to indicate their usefulness and/orsignificance in the opinion of the experts. Fields may include free-formentry fields such as text-entry fields where an expert may be able totype or otherwise enter text, enabling expert to propose or suggestcategories not currently recorded. Graphical user interface 124 or thelike may include fields corresponding to prognostic labels, whereexperts may enter data describing prognostic labels and/or categories ofprognostic labels the experts consider related to entered categories ofphysiological data; for instance, such fields may include drop-downlists or other pre-populated data entry fields listing currentlyrecorded prognostic labels, and which may be comprehensive, permittingeach expert to select a prognostic label and/or a plurality ofprognostic labels the expert believes to be predicted and/or associatedwith each category of physiological data selected by the expert. Fieldsfor entry of prognostic labels and/or categories of prognostic labelsmay include free-form data entry fields such as text entry fields; asdescribed above, examiners may enter data not presented in pre-populateddata fields in the free-form data entry fields. Alternatively oradditionally, fields for entry of prognostic labels may enable an expertto select and/or enter information describing or linked to a category ofprognostic label that the expert considers significant, wheresignificance may indicate likely impact on longevity, mortality, qualityof life, or the like as described in further detail below. Graphicaluser interface 124 may provide an expert with a field in which toindicate a reference to a document describing significant categories ofphysiological data, relationships of such categories to prognosticlabels, and/or significant categories of prognostic labels. Any datadescribed above may alternatively or additionally be received fromexperts similarly organized in paper form, which may be captured andentered into data in a similar way, or in a textual form such as aportable document file (PDF) with examiner entries, or the like

Referring again to FIG. 1, data information describing significantcategories of physiological data, relationships of such categories toprognostic labels, and/or significant categories of prognostic labelsmay alternatively or additionally be extracted from one or moredocuments using a language processing module 128. Language processingmodule 128 may include any hardware and/or software module. Languageprocessing module 128 may be configured to extract, from the one or moredocuments, one or more words. One or more words may include, withoutlimitation, strings of one or characters, including without limitationany sequence or sequences of letters, numbers, punctuation, diacriticmarks, engineering symbols, geometric dimensioning and tolerancing(GD&T) symbols, chemical symbols and formulas, spaces, whitespace, andother symbols, including any symbols usable as textual data as describedabove. Textual data may be parsed into tokens, which may include asimple word (sequence of letters separated by whitespace) or moregenerally a sequence of characters as described previously. The term“token,” as used herein, refers to any smaller, individual groupings oftext from a larger source of text; tokens may be broken up by word, pairof words, sentence, or other delimitation. These tokens may in turn beparsed in various ways. Textual data may be parsed into words orsequences of words, which may be considered words as well. Textual datamay be parsed into “n-grams”, where all sequences of n consecutivecharacters are considered. Any or all possible sequences of tokens orwords may be stored as “chains”, for example for use as a Markov chainor Hidden Markov Model.

Still referring to FIG. 1, language processing module 128 may compareextracted words to categories of physiological data recorded atdiagnostic engine 108, one or more prognostic labels recorded atdiagnostic engine 108, and/or one or more categories of prognosticlabels recorded at diagnostic engine 108; such data for comparison maybe entered on diagnostic engine 108 as described above using expert datainputs or the like. In an embodiment, one or more categories may beenumerated, to find total count of mentions in such documents.Alternatively or additionally, language processing module 128 mayoperate to produce a language processing model. Language processingmodel may include a program automatically generated by diagnostic engine108 and/or language processing module 128 to produce associationsbetween one or more words extracted from at least a document and detectassociations, including without limitation mathematical associations,between such words, and/or associations of extracted words withcategories of physiological data, relationships of such categories toprognostic labels, and/or categories of prognostic labels. Associationsbetween language elements, where language elements include for purposesherein extracted words, categories of physiological data, relationshipsof such categories to prognostic labels, and/or categories of prognosticlabels may include, without limitation, mathematical associations,including without limitation statistical correlations between anylanguage element and any other language element and/or languageelements. Statistical correlations and/or mathematical associations mayinclude probabilistic formulas or relationships indicating, forinstance, a likelihood that a given extracted word indicates a givencategory of physiological data, a given relationship of such categoriesto prognostic labels, and/or a given category of prognostic labels. As afurther example, statistical correlations and/or mathematicalassociations may include probabilistic formulas or relationshipsindicating a positive and/or negative association between at least anextracted word and/or a given category of physiological data, a givenrelationship of such categories to prognostic labels, and/or a givencategory of prognostic labels; positive or negative indication mayinclude an indication that a given document is or is not indicating acategory of physiological data, relationship of such category toprognostic labels, and/or category of prognostic labels is or is notsignificant. For instance, and without limitation, a negative indicationmay be determined from a phrase such as “telomere length was not foundto be an accurate predictor of overall longevity,” whereas a positiveindication may be determined from a phrase such as “telomere length wasfound to be an accurate predictor of dementia,” as an illustrativeexample; whether a phrase, sentence, word, or other textual element in adocument or corpus of documents constitutes a positive or negativeindicator may be determined, in an embodiment, by mathematicalassociations between detected words, comparisons to phrases and/or wordsindicating positive and/or negative indicators that are stored in memoryat diagnostic engine 108, or the like.

Still referring to FIG. 1, language processing module 128 and/ordiagnostic engine 108 may generate the language processing model by anysuitable method, including without limitation a natural languageprocessing classification algorithm; language processing model mayinclude a natural language process classification model that enumeratesand/or derives statistical relationships between input term and outputterms. Algorithm to generate language processing model may include astochastic gradient descent algorithm, which may include a method thatiteratively optimizes an objective function, such as an objectivefunction representing a statistical estimation of relationships betweenterms, including relationships between input terms and output terms, inthe form of a sum of relationships to be estimated. In an alternative oradditional approach, sequential tokens may be modeled as chains, servingas the observations in a Hidden Markov Model (HMM). HMMs as used herein,are statistical models with inference algorithms that that may beapplied to the models. In such models, a hidden state to be estimatedmay include an association between an extracted word category ofphysiological data, a given relationship of such categories toprognostic labels, and/or a given category of prognostic labels. Theremay be a finite number of category of physiological data, a givenrelationship of such categories to prognostic labels, and/or a givencategory of prognostic labels to which an extracted word may pertain; anHMM inference algorithm, such as the forward-backward algorithm or theViterbi algorithm, may be used to estimate the most likely discretestate given a word or sequence of words. Language processing module 128may combine two or more approaches. For instance, and withoutlimitation, machine-learning program may use a combination ofNaive-Bayes (NB), Stochastic Gradient Descent (SGD), and parametergrid-searching classification techniques; the result may include aclassification algorithm that returns ranked associations.

Continuing to refer to FIG. 1, generating language processing model mayinclude generating a vector space, which may be a collection of vectors,defined as a set of mathematical objects that can be added togetherunder an operation of addition following properties of associativity,commutativity, existence of an identity element, and existence of aninverse element for each vector, and can be multiplied by scalar valuesunder an operation of scalar multiplication compatible with fieldmultiplication, and that has an identity element is distributive withrespect to vector addition, and is distributive with respect to fieldaddition. Each vector in an n-dimensional vector space may berepresented by an n-tuple of numerical values. Each unique extractedword and/or language element as described above may be represented by avector of the vector space. In an embodiment, each unique extractedand/or other language element may be represented by a dimension ofvector space; as a non-limiting example, each element of a vector mayinclude a number representing an enumeration of co-occurrences of theword and/or language element represented by the vector with another wordand/or language element. Vectors may be normalized, scaled according torelative frequencies of appearance and/or file sizes. In an embodimentassociating language elements to one another as described above mayinclude computing a degree of vector similarity between a vectorrepresenting each language element and a vector representing anotherlanguage element; vector similarity may be measured according to anynorm for proximity and/or similarity of two vectors, including withoutlimitation cosine similarity, which measures the similarity of twovectors by evaluating the cosine of the angle between the vectors, whichcan be computed using a dot product of the two vectors divided by thelengths of the two vectors. Degree of similarity may include any othergeometric measure of distance between vectors.

Still referring to FIG. 1, language processing module 128 may use acorpus of documents to generate associations between language elementsin a language processing module 128, and diagnostic engine 108 may thenuse such associations to analyze words extracted from one or moredocuments and determine that the one or more documents indicatesignificance of a category of physiological data, a given relationshipof such categories to prognostic labels, and/or a given category ofprognostic labels. In an embodiment, diagnostic engine 108 may performthis analysis using a selected set of significant documents, such asdocuments identified by one or more experts as representing goodscience, good clinical analysis, or the like; experts may identify orenter such documents via graphical user interface as described above inreference to FIG. 9, or may communicate identities of significantdocuments according to any other suitable method of electroniccommunication, or by providing such identity to other persons who mayenter such identifications into diagnostic engine 108. Documents may beentered into diagnostic engine 108 by being uploaded by an expert orother persons using, without limitation, file transfer protocol (FTP) orother suitable methods for transmission and/or upload of documents;alternatively or additionally, where a document is identified by acitation, a uniform resource identifier (URI), uniform resource locator(URL) or other datum permitting unambiguous identification of thedocument, diagnostic engine 108 may automatically obtain the documentusing such an identifier, for instance by submitting a request to adatabase or compendium of documents such as JSTOR as provided by IthakaHarbors, Inc. of New York.

Continuing to refer to FIG. 1, whether an entry indicating significanceof a category of physiological data, a given relationship of suchcategories to prognostic labels, and/or a given category of prognosticlabels is entered via graphical user interface, alternative submissionmeans, and/or extracted from a document or body of documents asdescribed above, an entry or entries may be aggregated to indicate anoverall degree of significance. For instance, each category ofphysiological data, relationship of such categories to prognosticlabels, and/or category of prognostic labels may be given an overallsignificance score; overall significance score may, for instance, beincremented each time an expert submission and/or paper indicatessignificance as described above. Persons skilled in the art, uponreviewing the entirety of this disclosure will be aware of other ways inwhich scores may be generated using a plurality of entries, includingaveraging, weighted averaging, normalization, and the like. Significancescores may be ranked; that is, all categories of physiological data,relationships of such categories to prognostic labels, and/or categoriesof prognostic labels may be ranked according significance scores, forinstance by ranking categories of physiological data, relationships ofsuch categories to prognostic labels, and/or categories of prognosticlabels higher according to higher significance scores and loweraccording to lower significance scores. Categories of physiologicaldata, relationships of such categories to prognostic labels, and/orcategories of prognostic labels may be eliminated from current use ifthey fail a threshold comparison, which may include a comparison ofsignificance score to a threshold number, a requirement thatsignificance score belong to a given portion of ranking such as athreshold percentile, quartile, or number of top-ranked scores.Significance scores may be used to filter outputs as described infurther detail below; for instance, where a number of outputs aregenerated and automated selection of a smaller number of outputs isdesired, outputs corresponding to higher significance scores may beidentified as more probable and/or selected for presentation while otheroutputs corresponding to lower significance scores may be eliminated.Alternatively or additionally, significance scores may be calculated persample type; for instance, entries by experts, documents, and/ordescriptions of purposes of a given type of physiological test or samplecollection as described above may indicate that for that type ofphysiological test or sample collection a first category ofphysiological data, relationship of such category to prognostic labels,and/or category of prognostic labels is significant with regard to thattest, while a second category of physiological data, relationship ofsuch category to prognostic labels, and/or category of prognostic labelsis not significant; such indications may be used to perform asignificance score for each category of physiological data, relationshipof such category to prognostic labels, and/or category of prognosticlabels is or is not significant per type of physiological sample, whichthen may be subjected to ranking, comparison to thresholds and/orelimination as described above.

Still referring to FIG. 1, diagnostic engine 108 may detect furthersignificant categories of physiological data, relationships of suchcategories to prognostic labels, and/or categories of prognostic labelsusing machine-learning processes, including without limitationunsupervised machine-learning processes as described in further detailbelow; such newly identified categories, as well as categories enteredby experts in free-form fields as described above, may be added topre-populated lists of categories, lists used to identify languageelements for language learning module, and/or lists used to identifyand/or score categories detected in documents, as described above.

Continuing to refer to FIG. 1, in an embodiment, diagnostic engine 108may be configured, for instance as part of receiving the first trainingset 112, to associate at least correlated first prognostic label 120with at least a category from a list of significant categories ofprognostic labels. Significant categories of prognostic labels may beacquired, determined, and/or ranked as described above. As anon-limiting example, prognostic labels may be organized according torelevance to and/or association with a list of significant conditions. Alist of significant conditions may include, without limitation,conditions having generally acknowledged impact on longevity and/orquality of life; this may be determined, as a non-limiting example, by aproduct of relative frequency of a condition within the population withyears of life and/or years of able-bodied existence lost, on average, asa result of the condition. A list of conditions may be modified for agiven person to reflect a family history of the person; for instance, aperson with a significant family history of a particular condition orset of conditions, or a genetic profile having a similarly significantassociation therewith, may have a higher probability of developing suchconditions than a typical person from the general population, and as aresult diagnostic engine 108 may modify list of significant categoriesto reflect this difference.

Still referring to FIG. 1, diagnostic engine 108 is designed andconfigured to receive a second training set 132 including a plurality ofsecond data entries. Each second data entry of the second training set132 includes at least a second prognostic label 136; at least a secondprognostic label 136 may include any label suitable for use as at leasta first prognostic label 120 as described above. Each second data entryof the second training set 132 includes at least an ameliorative processlabel 140 correlated with the at least a second prognostic label 136,where correlation may include any correlation suitable for correlationof at least a first prognostic label 120 to at least an element ofphysiological data as described above. As used herein, an ameliorativeprocess label 140 is an identifier, which may include any form ofidentifier suitable for use as a prognostic label as described above,identifying a process that tends to improve a physical condition of auser, where a physical condition of a user may include, withoutlimitation, any physical condition identifiable using a prognosticlabel. Ameliorative processes may include, without limitation, exerciseprograms, including amount, intensity, and/or types of exerciserecommended. Ameliorative processes may include, without limitation,dietary or nutritional recommendations based on data includingnutritional content, digestibility, or the like. Ameliorative processesmay include one or more medical procedures. Ameliorative processes mayinclude one or more physical, psychological, or other therapies.Ameliorative processes may include one or more medications. Personsskilled in the art, upon reviewing the entirety of this disclosure, willbe aware of various processes that may be used as ameliorative processesconsistently with this disclosure.

Continuing to refer to FIG. 1, in an embodiment diagnostic engine 108may be configured, for instance as part of receiving second training set132, to associate the at least second prognostic label 136 with at leasta category from a list of significant categories of prognostic labels.This may be performed as described above for use of lists of significantcategories with regard to at least a first prognostic label 120.Significance may be determined, and/or association with at least acategory, may be performed for prognostic labels in first training set112 according to a first process as described above and for prognosticlabels in second training set 132 according to a second process asdescribed above.

Still referring to FIG. 1, diagnostic engine 108 may be configured, forinstance as part of receiving second training set 132, to associate atleast a correlated ameliorative process label 140 with at least acategory from a list of significant categories of ameliorative processlabels 136. In an embodiment, diagnostic engine 108 and/or a user deviceconnected to diagnostic engine 108 may provide a second graphical userinterface 144 which may include without limitation a form or othergraphical element having data entry fields, wherein one or more experts,including without limitation clinical and/or scientific experts, mayenter information describing one or more categories of prognostic labelsthat the experts consider to be significant as described above; fieldsin graphical user interface may provide options describing previouslyidentified categories, which may include a comprehensive ornear-comprehensive list of types of prognostic labels, for instance in“drop-down” lists, where experts may be able to select one or moreentries to indicate their usefulness and/or significance in the opinionof the experts. Fields may include free-form entry fields such astext-entry fields where an expert may be able to type or otherwise entertext, enabling expert to propose or suggest categories not currentlyrecorded. Graphical user interface or the like may include fieldscorresponding to ameliorative labels, where experts may enter datadescribing ameliorative labels and/or categories of ameliorative labelsthe experts consider related to entered categories of prognostic labels;for instance, such fields may include drop-down lists or otherpre-populated data entry fields listing currently recorded ameliorativelabels, and which may be comprehensive, permitting each expert to selectan ameliorative label and/or a plurality of ameliorative labels theexpert believes to be predicted and/or associated with each category ofprognostic labels selected by the expert. Fields for entry ofameliorative labels and/or categories of ameliorative labels may includefree-form data entry fields such as text entry fields; as describedabove, examiners may enter data not presented in pre-populated datafields in the free-form data entry fields. Alternatively oradditionally, fields for entry of ameliorative labels may enable anexpert to select and/or enter information describing or linked to acategory of ameliorative label that the expert considers significant,where significance may indicate likely impact on longevity, mortality,quality of life, or the like as described in further detail below.Graphical user interface may provide an expert with a field in which toindicate a reference to a document describing significant categories ofprognostic labels, relationships of such categories to ameliorativelabels, and/or significant categories of ameliorative labels. Suchinformation may alternatively be entered according to any other suitablemeans for entry of expert data as described above. Data concerningsignificant categories of prognostic labels, relationships of suchcategories to ameliorative labels, and/or significant categories ofameliorative labels may be entered using analysis of documents usinglanguage processing module 128 or the like as described above.

In an embodiment, and still referring to FIG. 1, diagnostic engine 108may extract at least a second data entry from one or more documents;extraction may be performed using any language processing method asdescribed above. Diagnostic engine 108 may be configured, for instanceas part of receiving second training set 132, to receive at least adocument describing at least a medical history and extract at least asecond data entry of plurality of second data entries from the at leasta document. A medical history document may include, for instance, adocument received from an expert and/or medical practitioner describingtreatment of a patient; document may be anonymized by removal of one ormore patient-identifying features from document. A medical historydocument may include a case study, such as a case study published in amedical journal or written up by an expert. A medical history documentmay contain data describing and/or described by a prognostic label; forinstance, the medical history document may list a diagnosis that amedical practitioner made concerning the patient, a finding that thepatient is at risk for a given condition and/or evinces some precursorstate for the condition, or the like. A medical history document maycontain data describing and/or described by an ameliorative processlabel 140; for instance, the medical history document may list atherapy, recommendation, or other ameliorative process that a medicalpractitioner described or recommended to a patient. A medical historydocument may describe an outcome; for instance, medical history documentmay describe an improvement in a condition describing or described by aprognostic label, and/or may describe that the condition did notimprove. Prognostic labels, ameliorative process labels 136, and/orefficacy of ameliorative process labels 136 may be extracted from and/ordetermined from one or more medical history documents using anyprocesses for language processing as described above; for instance,language processing module 128 may perform such processes. As anon-limiting example, positive and/or negative indications regardingameliorative processes identified in medical history documents may bedetermined in a manner described above for determination of positiveand/or negative indications regarding categories of physiological data,relationships of such categories to prognostic labels, and/or categoriesof prognostic labels.

With continued reference to FIG. 2, diagnostic engine 108 may beconfigured to have a feedback mechanism. In an embodiment, diagnosticengine 108 may be configured to receive a first training set 200 and/ora second training set 220 generated by system 100. For example, dataabout a user that has been previously been analyzed by diagnostic engine108 may be utilized in algorithms by first model 240 and/or second model248. Such algorithms may be continuously updated as a function of suchdata. In yet another embodiment, data analyzed by language processingmodule 216 may be utilized as part of training data generatingalgorithms by first model 240 and/or second model 248 and/or any othermachine learning process performed by diagnostic engine 108.

With continued reference to FIG. 1, diagnostic engine 108 may beconfigured, for instance as part of receiving second training set 132,to receiving at least a second data entry of the plurality of seconddata entries from at least an expert. This may be performed, withoutlimitation using second graphical user interface as described above.

Referring now to FIG. 2, data incorporated in first training set 112and/or second training set 132 may be incorporated in one or moredatabases. As a non-limiting example, one or elements of physiologicalstate data may be stored in and/or retrieved from a biologicalextraction database 200. A biological extraction database 200 mayinclude any data structure for ordered storage and retrieval of data,which may be implemented as a hardware or software module. A biologicalextraction database 200 may be implemented, without limitation, as arelational database, a key-value retrieval datastore such as a NOSQLdatabase, or any other format or structure for use as a datastore that aperson skilled in the art would recognize as suitable upon review of theentirety of this disclosure. A biological extraction database 200 mayinclude a plurality of data entries and/or records corresponding toelements of physiological data as described above. Data entries and/orrecords may describe, without limitation, data concerning particularphysiological samples that have been collected; entries may describereasons for collection of samples, such as without limitation one ormore conditions being tested for, which may be listed with relatedprognostic labels. Data entries may include prognostic labels and/orother descriptive entries describing results of evaluation of pastphysiological samples, including diagnoses that were associated withsuch samples, prognoses and/or conclusions regarding likelihood offuture diagnoses that were associated with such samples, and/or othermedical or diagnostic conclusions that were derived. Such conclusionsmay have been generated by system 100 in previous iterations of methods,with or without validation of correctness by medical professionals. Dataentries in a biological extraction database 200 may be flagged with orlinked to one or more additional elements of information, which may bereflected in data entry cells and/or in linked tables such as tablesrelated by one or more indices in a relational database; one or moreadditional elements of information may include data associating aphysiological sample and/or a person from whom a physiological samplewas extracted or received with one or more cohorts, includingdemographic groupings such as ethnicity, sex, age, income, geographicalregion, or the like, one or more common diagnoses or physiologicalattributes shared with other persons having physiological samplesreflected in other data entries, or the like. Additional elements ofinformation may include one or more categories of physiological data asdescribed above. Additional elements of information may includedescriptions of particular methods used to obtain physiological samples,such as without limitation physical extraction of blood samples or thelike, capture of data with one or more sensors, and/or any otherinformation concerning provenance and/or history of data acquisition.Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various ways in which data entries in abiological extraction database 200 may reflect categories, cohorts,and/or populations of data consistently with this disclosure.

Referring now to FIG. 3, one or more database tables in biologicalextraction database 200 may include, as a non-limiting example, aprognostic link table 300. Prognostic link table 300 may be a tablerelating physiological sample data as described above to prognosticlabels; for instance, where an expert has entered data relating aprognostic label to a category of physiological sample data and/or to anelement of physiological sample data via first graphical user interface124 as described above, one or more rows recording such an entry may beinserted in prognostic link table 300. Alternatively or additionally,linking of prognostic labels to physiological sample data may beperformed entirely in a prognostic label database as described below.

With continued reference to FIG. 3, biological extraction database 200may include tables listing one or more samples according to samplesource. For instance, and without limitation, biological extractiondatabase 200 may include a fluid sample table 304 listing samplesacquired from a person by extraction of fluids, such as withoutlimitation blood, lymph cerebrospinal fluid, or the like. As anothernon-limiting example, biological extraction database 200 may include asensor data table 308, which may list samples acquired using one or moresensors, for instance as described in further detail below. As a furthernon-limiting example, biological extraction database 200 may include agenetic sample table 312, which may list partial or entire sequences ofgenetic material. Genetic material may be extracted and amplified, as anon-limiting example, using polymerase chain reactions (PCR) or thelike. As a further example, also non-limiting, biological extractiondatabase 200 may include a medical report table 316, which may listtextual descriptions of medical tests, including without limitationradiological tests or tests of strength and/or dexterity or the like.Data in medical report table may be sorted and/or categorized using alanguage processing module 312, for instance, translating a textualdescription into a numerical value and a label corresponding to acategory of physiological data; this may be performed using any languageprocessing algorithm or algorithms as referred to in this disclosure. Asanother non-limiting example, biological extraction database 200 mayinclude a tissue sample table 320, which may record physiologicalsamples obtained using tissue samples. Tables presented above arepresented for exemplary purposes only; persons skilled in the art willbe aware of various ways in which data may be organized in biologicalextraction database 200 consistently with this disclosure.

Referring again to FIG. 2, diagnostic engine 108 and/or another devicein system 100 may populate one or more fields in biological extractiondatabase 200 using expert information, which may be extracted orretrieved from an expert knowledge database 204. An expert knowledgedatabase 204 may include any data structure and/or data store suitablefor use as a biological extraction database 200 as described above.Expert knowledge database 204 may include data entries reflecting one ormore expert submissions of data such as may have been submittedaccording to any process described above in reference to FIG. 1,including without limitation by using first graphical user interface 124and/or second graphical user interface 140. Expert knowledge databasemay include one or more fields generated by language processing module128, such as without limitation fields extracted from one or moredocuments as described above. For instance, and without limitation, oneor more categories of physiological data and/or related prognosticlabels and/or categories of prognostic labels associated with an elementof physiological state data as described above may be stored ingeneralized from in an expert knowledge database 204 and linked to,entered in, or associated with entries in a biological extractiondatabase 200. Documents may be stored and/or retrieved by diagnosticengine 108 and/or language processing module 128 in and/or from adocument database 208; document database 208 may include any datastructure and/or data store suitable for use as biological extractiondatabase 200 as described above. Documents in document database 208 maybe linked to and/or retrieved using document identifiers such as URIand/or URL data, citation data, or the like; persons skilled in the art,upon reviewing the entirety of this disclosure, will be aware of variousways in which documents may be indexed and retrieved according tocitation, subject matter, author, date, or the like as consistent withthis disclosure.

Referring now to FIG. 4, an exemplary embodiment of an expert knowledgedatabase 204 is illustrated. Expert knowledge database 204 may, as anon-limiting example, organize data stored in the expert knowledgedatabase 204 according to one or more database tables. One or moredatabase tables may be linked to one another by, for instance, commoncolumn values. For instance, a common column between two tables ofexpert knowledge database 200 may include an identifier of an expertsubmission, such as a form entry, textual submission, expert paper, orthe like, for instance as defined below; as a result, a query may beable to retrieve all rows from any table pertaining to a givensubmission or set thereof. Other columns may include any other categoryusable for organization or subdivision of expert data, including typesof expert data, names and/or identifiers of experts submitting the data,times of submission, or the like; persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of various waysin which expert data from one or more tables may be linked and/orrelated to expert data in one or more other tables.

Still referring to FIG. 4, one or more database tables in expertknowledge database 204 may include, as a non-limiting example, an expertprognostic table 400. Expert prognostic table 400 may be a tablerelating physiological sample data as described above to prognosticlabels; for instance, where an expert has entered data relating aprognostic label to a category of physiological sample data and/or to anelement of physiological sample data via first graphical user interface120 as described above, one or more rows recording such an entry may beinserted in expert prognostic table 400. In an embodiment, a formsprocessing module 404 may sort data entered in a submission via firstgraphical user interface 120 by, for instance, sorting data from entriesin the first graphical user interface 120 to related categories of data;for instance, data entered in an entry relating in the first graphicaluser interface 120 to a prognostic label may be sorted into variablesand/or data structures for storage of prognostic labels, while dataentered in an entry relating to a category of physiological data and/oran element thereof may be sorted into variables and/or data structuresfor the storage of, respectively, categories of physiological data orelements of physiological data. Where data is chosen by an expert frompre-selected entries such as drop-down lists, data may be storeddirectly; where data is entered in textual form, language processingmodule 128 may be used to map data to an appropriate existing label, forinstance using a vector similarity test or other synonym-sensitivelanguage processing test to map physiological data to an existing label.Alternatively or additionally, when a language processing algorithm,such as vector similarity comparison, indicates that an entry is not asynonym of an existing label, language processing module may indicatethat entry should be treated as relating to a new label; this may bedetermined by, e.g., comparison to a threshold number of cosinesimilarity and/or other geometric measures of vector similarity of theentered text to a nearest existent label, and determination that adegree of similarity falls below the threshold number and/or a degree ofdissimilarity falls above the threshold number. Data from expert textualsubmissions 408, such as accomplished by filling out a paper or PDF formand/or submitting narrative information, may likewise be processed usinglanguage processing module 128. Data may be extracted from expert papers412, which may include without limitation publications in medical and/orscientific journals, by language processing module 128 via any suitableprocess as described herein. Persons skilled in the art, upon reviewingthe entirety of this disclosure, will be aware of various additionalmethods whereby novel terms may be separated from already-classifiedterms and/or synonyms therefore, as consistent with this disclosure.Expert prognostic table 400 may include a single table and/or aplurality of tables; plurality of tables may include tables forparticular categories of prognostic labels such as a current diagnosistable, a future prognosis table, a genetic tendency table, a metabolictendency table, and/or an endocrinal tendency table (not shown), to namea few non-limiting examples presented for illustrative purposes only.

With continued reference to FIG. 4, one or more database tables inexpert knowledge database 204 may include, as a further non-limitingexample tables listing one or more ameliorative process labels; expertdata populating such tables may be provided, without limitation, usingany process described above, including entry of data from secondgraphical user interface 140 via forms processing module 404 and/orlanguage processing module 128, processing of textual submissions 408,or processing of expert papers 412. For instance, and withoutlimitation, an ameliorative nutrition table 416 may list one or moreameliorative processes based on nutritional instructions, and/or linksof such one or more ameliorative processes to prognostic labels, asprovided by experts according to any method of processing and/orentering expert data as described above. As a further example anameliorative action table 420 may list one or more ameliorativeprocesses based on instructions for actions a user should take,including without limitation exercise, meditation, and/or cessation ofharmful eating, substance abuse, or other habits, and/or links of suchone or more ameliorative processes to prognostic labels, as provided byexperts according to any method of processing and/or entering expertdata as described above. As an additional example, an ameliorativesupplement table 424 may list one or more ameliorative processes basedon nutritional supplements, such as vitamin pills or the like, and/orlinks of such one or more ameliorative processes to prognostic labels,as provided by experts according to any method of processing and/orentering expert data as described above. As a further non-limitingexample, an ameliorative medication table 428 may list one or moreameliorative processes based on medications, including withoutlimitation over-the-counter and prescription pharmaceutical drugs,and/or links of such one or more ameliorative processes to prognosticlabels, as provided by experts according to any method of processingand/or entering expert data as described above. As an additionalexample, a counterindication table 432 may list one or morecounter-indications for one or more ameliorative processes;counterindications may include, without limitation allergies to one ormore foods, medications, and/or supplements, side-effects of one or moremedications and/or supplements, interactions between medications, foods,and/or supplements, exercises that should not be used given one or moremedical conditions, injuries, disabilities, and/or demographiccategories, or the like. Tables presented above are presented forexemplary purposes only; persons skilled in the art will be aware ofvarious ways in which data may be organized in expert knowledge database204 consistently with this disclosure.

Referring again to FIG. 2, a prognostic label database 212, which may beimplemented in any manner suitable for implementation of biologicalextraction database 200, may be used to store prognostic labels used insystem 100, including any prognostic labels correlated with elements ofphysiological data in first training set 112 as described above;prognostic labels may be linked to or refer to entries in biologicalextraction database 200 to which prognostic labels correspond. Linkingmay be performed by reference to historical data concerningphysiological samples, such as diagnoses, prognoses, and/or othermedical conclusions derived from physiological samples in the past;alternatively or additionally, a relationship between a prognostic labeland a data entry in biological extraction database 200 may be determinedby reference to a record in an expert knowledge database 204 linking agiven prognostic label to a given category of physiological sample asdescribed above. Entries in prognostic label database 212 may beassociated with one or more categories of prognostic labels as describedabove, for instance using data stored in and/or extracted from an expertknowledge database 204.

Referring now to FIG. 5, an exemplary embodiment of a prognostic labeldatabase 212 is illustrated. Prognostic label database 212 may, as anon-limiting example, organize data stored in the prognostic labeldatabase 212 according to one or more database tables. One or moredatabase tables may be linked to one another by, for instance, commoncolumn values. For instance, a common column between two tables ofprognostic label database 212 may include an identifier of an expertsubmission, such as a form entry, textual submission, expert paper, orthe like, for instance as defined below; as a result, a query may beable to retrieve all rows from any table pertaining to a givensubmission or set thereof. Other columns may include any other categoryusable for organization or subdivision of expert data, including typesof expert data, names and/or identifiers of experts submitting the data,times of submission, or the like; persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of various waysin which expert data from one or more tables may be linked and/orrelated to expert data in one or more other tables.

Still referring to FIG. 5, one or more database tables in prognosticlabel database 212 may include, as a non-limiting example, a sample datatable 500. Sample data table 500 may be a table listing sample data,along with, for instance, one or more linking columns to link such datato other information stored in prognostic label database 212. In anembodiment, sample data 504 may be acquired, for instance frombiological extraction database 200, in a raw or unsorted form, and maybe translated into standard forms, such as standard units ofmeasurement, labels associated with particular physiological datavalues, or the like; this may be accomplished using a datastandardization module 508, which may perform unit conversions. Datastandardization module 508 may alternatively or additionally map textualinformation, such as labels describing values tested for or the like,using language processing module 128 or equivalent components and/oralgorithms thereto.

Continuing to refer to FIG. 5, prognostic label database 212 may includea sample label table 512; sample label table 512 may list prognosticlabels received with and/or extracted from physiological samples, forinstance as received in the form of sample text 516. A languageprocessing module 128 may compare textual information so received toprognostic labels and/or form new prognostic labels according to anysuitable process as described above. Sample prognostic link table maycombine samples with prognostic labels, as acquired from sample labeltable and/or expert knowledge database 204; combination may be performedby listing together in rows or by relating indices or common columns oftwo or more tables to each other. Tables presented above are presentedfor exemplary purposes only; persons skilled in the art will be aware ofvarious ways in which data may be organized in expert knowledge database204 consistently with this disclosure.

Referring again to FIG. 2, first training set 112 may be populated byretrieval of one or more records from biological extraction database 200and/or prognostic label database 212; in an embodiment, entriesretrieved from biological extraction database 200 and/or prognosticlabel database 212 may be filtered and or select via query to match oneor more additional elements of information as described above, so as toretrieve a first training set 112 including data belonging to a givencohort, demographic population, or other set, so as to generate outputsas described below that are tailored to a person or persons with regardto whom system 100 classifies physiological samples to prognostic labelsas set forth in further detail below. Persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of various waysin which records may be retrieved from biological extraction database200 and/or prognostic label database to generate a first training set toreflect individualized group data pertaining to a person of interest inoperation of system and/or method, including without limitation a personwith regard to whom at least a physiological sample is being evaluatedas described in further detail below. Diagnostic engine 108 mayalternatively or additionally receive a first training set 112 and storeone or more entries in biological extraction database 200 and/orprognostic label database 212 as extracted from elements of firsttraining set 112.

Still referring to FIG. 2, system 100 may include or communicate with anameliorative process label database 216; an ameliorative process labeldatabase 216 may include any data structure and/or datastore suitablefor use as a biological extraction database 200 as described above. Anameliorative process label database 216 may include one or more entrieslisting labels associated with one or more ameliorative processes asdescribed above, including any ameliorative labels correlated withprognostic labels in second training set 132 as described above;ameliorative process labels may be linked to or refer to entries inprognostic label database 212 to which ameliorative process labelscorrespond. Linking may be performed by reference to historical dataconcerning prognostic labels, such as therapies, treatments, and/orlifestyle or dietary choices chosen to alleviate conditions associatedwith prognostic labels in the past; alternatively or additionally, arelationship between an ameliorative process label and a data entry inprognostic label database 212 may be determined by reference to a recordin an expert knowledge database 204 linking a given ameliorative processlabel to a given category of prognostic label as described above.Entries in ameliorative process label database 212 may be associatedwith one or more categories of prognostic labels as described above, forinstance using data stored in and/or extracted from an expert knowledgedatabase 204.

Referring now to FIG. 6, an exemplary embodiment of an ameliorativeprocess label database 216 is illustrated. Ameliorative process labeldatabase 216 may, as a non-limiting example, organize data stored in theameliorative process label database 216 according to one or moredatabase tables. One or more database tables may be linked to oneanother by, for instance, common column values. For instance, a commoncolumn between two tables of ameliorative process label database 216 mayinclude an identifier of an expert submission, such as a form entry,textual submission, expert paper, or the like, for instance as definedbelow; as a result, a query may be able to retrieve all rows from anytable pertaining to a given submission or set thereof. Other columns mayinclude any other category usable for organization or subdivision ofexpert data, including types of expert data, names and/or identifiers ofexperts submitting the data, times of submission, or the like; personsskilled in the art, upon reviewing the entirety of this disclosure, willbe aware of various ways in which expert data from one or more tablesmay be linked and/or related to expert data in one or more other tables.

Still referring to FIG. 6, ameliorative process label database 216 mayinclude a prognostic link table 600; prognostic link table may linkameliorative process data to prognostic label data, using any suitablemethod for linking data in two or more tables as described above.Ameliorative process label database 216 may include an ameliorativenutrition table 604, which may list one or more ameliorative processesbased on nutritional instructions, and/or links of such one or moreameliorative processes to prognostic labels, for instance as provided byexperts according to any method of processing and/or entering expertdata as described above, and/or using one or more machine-learningprocesses as set forth in further detail below. As a further example anameliorative action table 608 may list one or more ameliorativeprocesses based on instructions for actions a user should take,including without limitation exercise, meditation, and/or cessation ofharmful eating, substance abuse, or other habits, and/or links of suchone or more ameliorative processes to prognostic labels, as provided byexperts according to any method of processing and/or entering expertdata as described above and/or using one or more machine-learningprocesses as set forth in further detail below. As an additionalexample, an ameliorative supplement table 612 may list one or moreameliorative processes based on nutritional supplements, such as vitaminpills or the like, and/or links of such one or more ameliorativeprocesses to prognostic labels, as provided by experts according to anymethod of processing and/or entering expert data as described aboveand/or using one or more machine-learning processes as set forth infurther detail below. As a further non-limiting example, an ameliorativemedication table 616 may list one or more ameliorative processes basedon medications, including without limitation over-the-counter andprescription pharmaceutical drugs, and/or links of such one or moreameliorative processes to prognostic labels, as provided by expertsaccording to any method of processing and/or entering expert data asdescribed above and/or using one or more machine-learning processes asset forth in further detail below. As an additional example, acounterindication table 620 may list one or more counter-indications forone or more ameliorative processes; counterindications may include,without limitation allergies to one or more foods, medications, and/orsupplements, side-effects of one or more medications and/or supplements,interactions between medications, foods, and/or supplements, exercisesthat should not be used given one or more medical conditions, injuries,disabilities, and/or demographic categories, or the like; this may beacquired using expert submission as described above and/or using one ormore machine-learning processes as set forth in further detail below.Tables presented above are presented for exemplary purposes only;persons skilled in the art will be aware of various ways in which datamay be organized in ameliorative process database 216 consistently withthis disclosure.

Referring again to FIG. 2, second training set 132 may be populated byretrieval of one or more records from prognostic label database 212and/or ameliorative process label database 216; in an embodiment,entries retrieved from prognostic label database 212 and/or ameliorativeprocess label database 216 may be filtered and or select via query tomatch one or more additional elements of information as described above,so as to retrieve a second training set 132 including data belonging toa given cohort, demographic population, or other set, so as to generateoutputs as described below that are tailored to a person or persons withregard to whom system 100 classifies prognostic labels to ameliorativeprocess labels as set forth in further detail below. Persons skilled inthe art, upon reviewing the entirety of this disclosure, will be awareof various ways in which records may be retrieved from prognostic labeldatabase 212 and/or ameliorative process label database 216 to generatea second training set 132 to reflect individualized group datapertaining to a person of interest in operation of system and/or method,including without limitation a person with regard to whom at least aphysiological sample is being evaluated as described in further detailbelow. Diagnostic engine 108 may alternatively or additionally receive asecond training set 132 and store one or more entries in prognosticlabel database 212 and/or ameliorative process label database 216 asextracted from elements of second training set 132.

In an embodiment, and still referring to FIG. 2, diagnostic engine 108may receive an update to one or more elements of data represented infirst training set 112 and/or second training set 132 and may performone or more modifications to first training set 112 and/or secondtraining set 132, or to biological extraction database 200, expertknowledge database 204, prognostic label database 212, and/orameliorative process label database 216 as a result. For instance, aphysiological sample may turn out to have been erroneously recorded;diagnostic engine 108 may remove it from first training set 112, secondtraining set 132, biological extraction database 200, expert knowledgedatabase 204, prognostic label database 212, and/or ameliorative processlabel database 216 as a result. As a further example, a medical and/oracademic paper, or a study on which it was based, may be revoked;diagnostic engine 108 may remove it from first training set 112, secondtraining set 132, biological extraction database 200, expert knowledgedatabase 204, prognostic label database 212, and/or ameliorative processlabel database 216 as a result. Information provided by an expert maylikewise be removed if the expert loses credentials or is revealed tohave acted fraudulently.

Continuing to refer to FIG. 2, elements of data first training set 112,second training set 132, biological extraction database 200, expertknowledge database 204, prognostic label database 212, and/orameliorative process label database 216 may have temporal attributes,such as timestamps; diagnostic engine 108 may order such elementsaccording to recency, select only elements more recently entered forfirst training set 112 and/or second training set 132, or otherwise biastraining sets, database entries, and/or machine-learning models asdescribed in further detail below toward more recent or less recententries. Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various ways in which temporal attributesof data entries may be used to affect results of methods and/or systemsas described herein.

Referring again to FIG. 1, diagnostic engine 108 may be configured torecord at least a biological extraction. At least a biologicalextraction may include a physically extracted sample, which as usedherein, includes a sample obtained by removing and analyzing tissueand/or fluid. Physically extracted sample may include without limitationa blood sample, a tissue sample, a buccal swab, a mucous sample, a stoolsample, a hair sample, a fingernail sample, or the like. Physicallyextracted sample may include, as a non-limiting example, at least ablood sample. As a further non-limiting example, at least a biologicalextraction may include at least a genetic sample. At least a geneticsample may include a complete genome of a person or any portion thereof.At least a genetic sample may include a DNA sample and/or an RNA sample.At least a biological extraction may include an epigenetic sample, aproteomic sample, a tissue sample, a biopsy, and/or any other physicallyextracted sample. At least a biological extraction may include anendocrinal sample. As a further non-limiting example, the at least abiological extraction may include a signal from at least a sensorconfigured to detect physiological data of a user and recording the atleast a biological extraction as a function of the signal. At least asensor 148 may include any medical sensor and/or medical deviceconfigured to capture sensor data concerning a patient, including anyscanning, radiological and/or imaging device such as without limitationx-ray equipment, computer assisted tomography (CAT) scan equipment,positron emission tomography (PET) scan equipment, any form of magneticresonance imagery (MRI) equipment, ultrasound equipment, opticalscanning equipment such as photo-plethysmographic equipment, or thelike. At least a sensor 148 may include any electromagnetic sensor,including without limitation electroencephalographic sensors,magnetoencephalographic sensors, electrocardiographic sensors,electromyographic sensors, or the like. At least a sensor 148 mayinclude a temperature sensor. At least a sensor 148 may include anysensor that may be included in a mobile device and/or wearable device,including without limitation a motion sensor such as an inertialmeasurement unit (IMU), one or more accelerometers, one or moregyroscopes, one or more magnetometers, or the like. At least a wearableand/or mobile device sensor may capture step, gait, and/or othermobility data, as well as data describing activity levels and/orphysical fitness. At least a wearable and/or mobile device sensor maydetect heart rate or the like. At least a sensor 148 may detect anyhematological parameter including blood oxygen level, pulse rate, heartrate, pulse rhythm, blood sugar, and/or blood pressure. At least asensor 108 may be configured to detect internal and/or externalbiomarkers and/or readings. At least a sensor 148 may be a part ofsystem 100 or may be a separate device in communication with system 100.

Still referring to FIG. 1, at least a biological extraction may includeany data suitable for use as physiological state data as describedabove, including without limitation any result of any medical test,physiological assessment, cognitive assessment, psychologicalassessment, or the like. System 100 may receive at least a biologicalextraction from one or more other devices after performance; system 100may alternatively or additionally perform one or more assessments and/ortests to obtain at least a biological extraction, and/or one or moreportions thereof, on system 100. For instance, at least biologicalextraction may include or more entries by a user in a form or similargraphical user interface object; one or more entries may include,without limitation, user responses to questions on a psychological,behavioral, personality, or cognitive test. For instance, at least aserver 104 may present to user a set of assessment questions designed orintended to evaluate a current state of mind of the user, a currentpsychological state of the user, a personality trait of the user, or thelike; at least a server 104 may provide user-entered responses to suchquestions directly as at least a biological extraction and/or mayperform one or more calculations or other algorithms to derive a scoreor other result of an assessment as specified by one or more testingprotocols, such as automated calculation of a Stanford-Binet and/orWechsler scale for IQ testing, a personality test scoring such as aMyers-Briggs test protocol, or other assessments that may occur topersons skilled in the art upon reviewing the entirety of thisdisclosure.

Alternatively or additionally, and with continued reference to FIG. 1,at least a biological extraction may include assessment and/orself-assessment data, and/or automated or other assessment results,obtained from a third-party device; third-party device may include,without limitation, a server or other device (not shown) that performsautomated cognitive, psychological, behavioral, personality, or otherassessments. Third-party device may include a device operated by aninformed advisor.

Still referring to FIG. 1, at least a biological extraction may includedata describing one or more test results, including results of mobilitytests, stress tests, dexterity tests, endocrinal tests, genetic tests,and/or electromyographic tests, biopsies, radiological tests, genetictests, and/or sensory tests. Persons skilled in the art, upon reviewingthe entirety of this disclosure, will be aware of various additionalexamples of at least a physiological sample consistent with thisdisclosure. At least a physiological sample may be added to biologicalextraction database 200.

With continued reference to FIG. 1, system 100 may include a prognosticlabel learner 152 operating on the diagnostic engine 108, the prognosticlabel learner 152 designed and configured to generate the at least aprognostic output as a function of the first training set 112 and the atleast a biological extraction. Prognostic label learner 152 may includeany hardware and/or software module. Prognostic label learner 152 isdesigned and configured to generate outputs using machine learningprocesses. A machine learning process is a process that automatedly usesa body of data known as “training data” and/or a “training set” togenerate an algorithm that will be performed by a computingdevice/module to produce outputs given data provided as inputs; this isin contrast to a non-machine learning software program where thecommands to be executed are determined in advance by a user and writtenin a programming language.

Still referring to FIG. 1, prognostic label learner 152 may be designedand configured to generate at least a prognostic output by creating atleast a first machine-learning model 152 relating physiological statedata 116 to prognostic labels using the first training set 112 andgenerating the at least a prognostic output using the firstmachine-learning model 152; at least a first machine-learning model 152may include one or more models that determine a mathematicalrelationship between physiological state data 116 and prognostic labels.Such models may include without limitation model developed using linearregression models. Linear regression models may include ordinary leastsquares regression, which aims to minimize the square of the differencebetween predicted outcomes and actual outcomes according to anappropriate norm for measuring such a difference (e.g. a vector-spacedistance norm); coefficients of the resulting linear equation may bemodified to improve minimization. Linear regression models may includeridge regression methods, where the function to be minimized includesthe least-squares function plus term multiplying the square of eachcoefficient by a scalar amount to penalize large coefficients. Linearregression models may include least absolute shrinkage and selectionoperator (LASSO) models, in which ridge regression is combined withmultiplying the least-squares term by a factor of 1 divided by doublethe number of samples. Linear regression models may include a multi-tasklasso model wherein the norm applied in the least-squares term of thelasso model is the Frobenius norm amounting to the square root of thesum of squares of all terms. Linear regression models may include theelastic net model, a multi-task elastic net model, a least angleregression model, a LARS lasso model, an orthogonal matching pursuitmodel, a Bayesian regression model, a logistic regression model, astochastic gradient descent model, a perceptron model, a passiveaggressive algorithm, a robustness regression model, a Huber regressionmodel, or any other suitable model that may occur to persons skilled inthe art upon reviewing the entirety of this disclosure. Linearregression models may be generalized in an embodiment to polynomialregression models, whereby a polynomial equation (e.g. a quadratic,cubic or higher-order equation) providing a best predicted output/actualoutput fit is sought; similar methods to those described above may beapplied to minimize error functions, as will be apparent to personsskilled in the art upon reviewing the entirety of this disclosure.

With continued reference to FIG. 1, machine-learning algorithms maygenerate prognostic output as a function of a classification of at leasta prognostic label. Classification as used herein includes pairing orgrouping prognostic labels as a function of a shared commonality.Classification may include for example, groupings, pairings, and/ortrends between physiological data and current prognostic label, futureprognostic label, and the like. In an embodiment, machine-learningalgorithms may examine relationships between a future propensity of auser to develop a condition based on current user physiological data.Machine-learning algorithms may include any and all algorithms asperformed by any modules, described herein for prognostic label learner152. For example, machine-learning algorithms may relate fasting bloodglucose readings of a user to user's future propensity to developdiabetes. Machine-learning algorithms may examine precursor conditionand future propensity to develop a subsequent disorder. For example,machine-learning algorithms may examine a user diagnosed with chickenpox and user's future propensity to subsequently develop shingles. Inyet another non-limiting example, machine-learning algorithms mayexamine infection with human papillomavirus (HPV) and subsequent cancerdiagnosis. Machine-learning algorithms may examine a user's propensityto have recurring attacks of a disease or condition, for example a userwith elevated uric acid levels and repeated attacks of gout.Machine-learning algorithms may examine user's genetic predisposition todevelop a certain condition or disease. For example, machine-learningalgorithms may examine presence of hereditary non-polyposis colorectalcancer (HNPCC) commonly known as lynch syndrome, and subsequentdiagnosis of colorectal cancer. In yet another non-limiting example,machine-learning algorithms may examine presence of abnormal squamouscells and/or abnormal glandular cells in the cervix and subsequentdevelopment of cervical cancer. Machine-learning algorithms may examineprogression of disease state, for example progression of humanimmunodeficiency virus (HIV) is marked by decline of CD4+ T-Cells, witha count below 200 leading to a diagnosis of acquired immunodeficiencysyndrome (AIDS). In yet another non-limiting example, progression ofdiabetes may be marked by increases of hemoglobin A1C levels with alevel of 6.5% indicating a diagnosis of diabetes. Machine-learningalgorithms may examine progression of disease by certain age groups. Forexample, progression of Multiple Sclerosis in users between the age of20-30 as compared to progression of Multiple Sclerosis in users betweenthe age of 70-80. Machine-learning algorithms may be examiningprogression of aging such as measurements of telomere length and/oroxidative stress levels and chance mortality risk. Machine-learningalgorithms may examine development of co-morbid conditions when adisease or conditions is already present. For example, machine-learningalgorithms may examine a user diagnosed with depression and subsequentdiagnosis of a co-morbid condition such as migraines, generalizedanxiety disorder, antisocial personality disorder, agoraphobia,obsessive-compulsive disorder, drug dependence alcohol dependence,and/or panic disorder. Machine-learning algorithms may examine a user'slifetime chance of developing a certain disease or condition, such as auser's lifetime risk of heart disease, Alzheimer's disease, diabetes andthe like. Machine-learning algorithms may be grouped and implementedaccording to any of the methodologies as described below in reference toFIG. 19.

Continuing to refer to FIG. 1, machine-learning algorithm used togenerate first machine-learning model 152 may include, withoutlimitation, linear discriminant analysis. Machine-learning algorithm mayinclude quadratic discriminate analysis. Machine-learning algorithms mayinclude kernel ridge regression. Machine-learning algorithms may includesupport vector machines, including without limitation support vectorclassification-based regression processes. Machine-learning algorithmsmay include stochastic gradient descent algorithms, includingclassification and regression algorithms based on stochastic gradientdescent. Machine-learning algorithms may include nearest neighbors'algorithms. Machine-learning algorithms may include Gaussian processessuch as Gaussian Process Regression. Machine-learning algorithms mayinclude cross-decomposition algorithms, including partial least squaresand/or canonical correlation analysis. Machine-learning algorithms mayinclude naive Bayes methods. Machine-learning algorithms may includealgorithms based on decision trees, such as decision tree classificationor regression algorithms. Machine-learning algorithms may includeensemble methods such as bagging meta-estimator, forest of randomizedtress, AdaBoost, gradient tree boosting, and/or voting classifiermethods. Machine-learning algorithms may include neural net algorithms,including convolutional neural net processes.

Still referring to FIG. 1, prognostic label learner 152 may generateprognostic output using alternatively or additional artificialintelligence methods, including without limitation by creating anartificial neural network, such as a convolutional neural networkcomprising an input layer of nodes, one or more intermediate layers, andan output layer of nodes. Connections between nodes may be created viathe process of “training” the network, in which elements from a trainingdataset are applied to the input nodes, a suitable training algorithm(such as Levenberg-Marquardt, conjugate gradient, simulated annealing,or other algorithms) is then used to adjust the connections and weightsbetween nodes in adjacent layers of the neural network to produce thedesired values at the output nodes. This process is sometimes referredto as deep learning. This network may be trained using first trainingset 112; the trained network may then be used to apply detectedrelationships between elements of physiological state data 116 andprognostic labels.

Referring now to FIG. 7, machine-learning algorithms used by prognosticlabel learner 152 may include supervised machine-learning algorithms,which may, as a non-limiting example be executed using a supervisedlearning module 700 executing on diagnostic engine 108 and/or on anothercomputing device in communication with diagnostic engine 108, which mayinclude any hardware or software module. Supervised machine learningalgorithms, as defined herein, include algorithms that receive atraining set relating a number of inputs to a number of outputs, andseek to find one or more mathematical relations relating inputs tooutputs, where each of the one or more mathematical relations is optimalaccording to some criterion specified to the algorithm using somescoring function. For instance, a supervised learning algorithm may useelements of physiological data as inputs, prognostic labels as outputs,and a scoring function representing a desired form of relationship to bedetected between elements of physiological data and prognostic labels;scoring function may, for instance, seek to maximize the probabilitythat a given element of physiological state data 116 and/or combinationof elements of physiological data is associated with a given prognosticlabel and/or combination of prognostic labels to minimize theprobability that a given element of physiological state data 116 and/orcombination of elements of physiological state data 116 is notassociated with a given prognostic label and/or combination ofprognostic labels. Scoring function may be expressed as a risk functionrepresenting an “expected loss” of an algorithm relating inputs tooutputs, where loss is computed as an error function representing adegree to which a prediction generated by the relation is incorrect whencompared to a given input-output pair provided in first training set112. Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various possible variations of supervisedmachine learning algorithms that may be used to determine relationbetween elements of physiological data and prognostic labels. In anembodiment, one or more supervised machine-learning algorithms may berestricted to a particular domain for instance, a supervisedmachine-learning process may be performed with respect to a given set ofparameters and/or categories of parameters that have been suspected tobe related to a given set of prognostic labels, and/or are specified aslinked to a medical specialty and/or field of medicine covering aparticular set of prognostic labels. As a non-limiting example, aparticular set of blood test biomarkers and/or sensor data may betypically used by cardiologists to diagnose or predict variouscardiovascular conditions, and a supervised machine-learning process maybe performed to relate those blood test biomarkers and/or sensor data tothe various cardiovascular conditions; in an embodiment, domainrestrictions of supervised machine-learning procedures may improveaccuracy of resulting models by ignoring artifacts in training data.Domain restrictions may be suggested by experts and/or deduced fromknown purposes for particular evaluations and/or known tests used toevaluate prognostic labels. Additional supervised learning processes maybe performed without domain restrictions to detect, for instance,previously unknown and/or unsuspected relationships betweenphysiological data and prognostic labels.

Referring again to FIG. 1, machine-learning algorithms may includeunsupervised processes; unsupervised processes may, as a non-limitingexample, be executed by an unsupervised learning module 704 executing ondiagnostic engine 108 and/or on another computing device incommunication with diagnostic engine 108, which may include any hardwareor software module. An unsupervised machine-learning process, as usedherein, is a process that derives inferences in datasets without regardto labels; as a result, an unsupervised machine-learning process may befree to discover any structure, relationship, and/or correlationprovided in the data. For instance, and without limitation, prognosticlabel learner 152 and/or diagnostic engine 108 may perform anunsupervised machine learning process on first training set 112, whichmay cluster data of first training set 112 according to detectedrelationships between elements of the first training set 112, includingwithout limitation correlations of elements of physiological state data116 to each other and correlations of prognostic labels to each other;such relations may then be combined with supervised machine learningresults to add new criteria for prognostic label learner 152 to apply inrelating physiological state data 116 to prognostic labels. As anon-limiting, illustrative example, an unsupervised process maydetermine that a first element of physiological data acquired in a bloodtest correlates closely with a second element of physiological data,where the first element has been linked via supervised learningprocesses to a given prognostic label, but the second has not; forinstance, the second element may not have been defined as an input forthe supervised learning process, or may pertain to a domain outside of adomain limitation for the supervised learning process. Continuing theexample a close correlation between first element of physiological statedata 116 and second element of physiological state data 116 may indicatethat the second element is also a good predictor for the prognosticlabel; second element may be included in a new supervised process toderive a relationship or may be used as a synonym or proxy for the firstphysiological element by prognostic label learner 152.

Still referring to FIG. 1, diagnostic engine 108 and/or prognostic labellearner 152 may detect further significant categories of physiologicaldata, relationships of such categories to prognostic labels, and/orcategories of prognostic labels using machine-learning processes,including without limitation unsupervised machine-learning processes asdescribed above; such newly identified categories, as well as categoriesentered by experts in free-form fields as described above, may be addedto pre-populated lists of categories, lists used to identify languageelements for language learning module, and/or lists used to identifyand/or score categories detected in documents, as described above. In anembodiment, as additional data is added to system 100, prognostic labellearner 152 and/or diagnostic engine 108 may continuously or iterativelyperform unsupervised machine-learning processes to detect relationshipsbetween different elements of the added and/or overall data; in anembodiment, this may enable system 100 to use detected relationships todiscover new correlations between known biomarkers, prognostic labels,and/or ameliorative labels and one or more elements of data in largebodies of data, such as genomic, proteomic, and/or microbiome-relateddata, enabling future supervised learning and/or lazy learning processesas described in further detail below to identify relationships between,e.g., particular clusters of genetic alleles and particular prognosticlabels and/or suitable ameliorative labels. Use of unsupervised learningmay greatly enhance the accuracy and detail with which system may detectprognostic labels and/or ameliorative labels.

With continued reference to FIG. 1, unsupervised processes may besubjected to domain limitations. For instance, and without limitation,an unsupervised process may be performed regarding a comprehensive setof data regarding one person, such as a comprehensive medical history,set of test results, and/or physiological data such as genomic,proteomic, and/or other data concerning that persons. As anothernon-limiting example, an unsupervised process may be performed on dataconcerning a particular cohort of persons; cohort may include, withoutlimitation, a demographic group such as a group of people having ashared age range, ethnic background, nationality, sex, and/or gender.Cohort may include, without limitation, a group of people having ashared value for an element and/or category of physiological data, agroup of people having a shared value for an element and/or category ofprognostic label, and/or a group of people having a shared value and/orcategory of ameliorative label; as illustrative examples, cohort couldinclude all people having a certain level or range of levels of bloodtriglycerides, all people diagnosed with type II diabetes, all peoplewho regularly run between 10 and 15 miles per week, or the like. Personsskilled in the art, upon reviewing the entirety of this disclosure, willbe aware of a multiplicity of ways in which cohorts and/or other sets ofdata may be defined and/or limited for a particular unsupervisedlearning process.

Still referring to FIG. 1, prognostic label learner 152 mayalternatively or additionally be designed and configured to generate atleast a prognostic output by executing a lazy learning process as afunction of the first training set 112 and the at least a biologicalextraction; lazy learning processes may be performed by a lazy learningmodule 708 executing on diagnostic engine 108 and/or on anothercomputing device in communication with diagnostic engine 108, which mayinclude any hardware or software module. A lazy-learning process and/orprotocol, which may alternatively be referred to as a “lazy loading” or“call-when-needed” process and/or protocol, may be a process wherebymachine learning is conducted upon receipt of an input to be convertedto an output, by combining the input and training set to derive thealgorithm to be used to produce the output on demand. For instance, aninitial set of simulations may be performed to cover a “first guess” ata prognostic label associated with biological extraction, using firsttraining set 112. As a non-limiting example, an initial heuristic mayinclude a ranking of prognostic labels according to relation to a testtype of at least a biological extraction, one or more categories ofphysiological data identified in test type of at least a biologicalextraction, and/or one or more values detected in at least a biologicalextraction; ranking may include, without limitation, ranking accordingto significance scores of associations between elements of physiologicaldata and prognostic labels, for instance as calculated as describedabove. Heuristic may include selecting some number of highest-rankingassociations and/or prognostic labels. Prognostic label learner 152 mayalternatively or additionally implement any suitable “lazy learning”algorithm, including without limitation a K-nearest neighbors algorithm,a lazy naïve Bayes algorithm, or the like; persons skilled in the art,upon reviewing the entirety of this disclosure, will be aware of variouslazy-learning algorithms that may be applied to generate prognosticoutputs as described in this disclosure, including without limitationlazy learning applications of machine-learning algorithms as describedin further detail below.

In an embodiment, and continuing to refer to FIG. 1, prognostic labellearner 152 may generate a plurality of prognostic labels havingdifferent implications for a particular person. For instance, where theat least a physiological sample includes a result of a dexterity test, alow score may be consistent with amyotrophic lateral sclerosis,Parkinson's disease, multiple sclerosis, and/or any number of less severdisorders or tendencies associated with lower levels of dexterity. Insuch a situation, prognostic label learner 152 and/or diagnostic engine108 may perform additional processes to resolve ambiguity. Processes mayinclude presenting multiple possible results to a medical practitioner,informing the medical practitioner that one or more follow-up testsand/or physiological samples are needed to further determine a moredefinite prognostic label. Alternatively or additionally, processes mayinclude additional machine learning steps; for instance, where referenceto a model generated using supervised learning on a limited domain hasproduced multiple mutually exclusive results and/or multiple resultsthat are unlikely all to be correct, or multiple different supervisedmachine learning models in different domains may have identifiedmutually exclusive results and/or multiple results that are unlikely allto be correct. In such a situation, prognostic label learner 152 and/ordiagnostic engine 108 may operate a further algorithm to determine whichof the multiple outputs is most likely to be correct; algorithm mayinclude use of an additional supervised and/or unsupervised model.Alternatively or additionally, prognostic label learner 152 may performone or more lazy learning processes using a more comprehensive set ofuser data to identify a more probably correct result of the multipleresults. Results may be presented and/or retained with rankings, forinstance to advise a medical professional of the relative probabilitiesof various prognostic labels being correct; alternatively oradditionally, prognostic labels associated with a probability ofcorrectness below a given threshold and/or prognostic labelscontradicting results of the additional process, may be eliminated. As anon-limiting example, an endocrinal test may determine that a givenperson has high levels of dopamine, indicating that a poor pegboardperformance is almost certainly not being caused by Parkinson's disease,which may lead to Parkinson's being eliminated from a list of prognosticlabels associated with poor pegboard performance, for that person.Similarly, a genetic test may eliminate Huntington's disease, or anotherdisease definitively linked to a given genetic profile, as a cause.Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various ways in which additional processingmay be used to determine relative likelihoods of prognostic labels on alist of multiple prognostic labels, and/or to eliminate some labels fromsuch a list. Prognostic output 712 may be provided to user output deviceas described in further detail below.

Still referring to FIG. 1, diagnostic engine 108 includes anameliorative process label learner 160 operating on the diagnosticengine 108, the ameliorative process label learner 160 designed andconfigured to generate the at least an ameliorative output as a functionof the second training set 132 and the at least a prognostic output.Ameliorative process label learner 160 may include any hardware orsoftware module suitable for use as a prognostic label learner 152 asdescribed above. Ameliorative process label learner 160 is amachine-learning module as described above; ameliorative process labellearner 160 may perform any machine-learning process or combination ofprocesses suitable for use by a prognostic label learner 152 asdescribed above. For instance, and without limitation, and ameliorativeprocess label learner 160 may be configured to create a secondmachine-learning model 160 relating prognostic labels to ameliorativelabels using the second training set 132 and generate the at least anameliorative output using the second machine-learning model 160; secondmachine-learning model 160 may be generated according to any process,process steps, or combination of processes and/or process steps suitablefor creation of first machine learning model. In an embodiment,ameliorative process label learner 160 may use data from first trainingset 112 as well as data from second training set 132; for instance,ameliorative process label learner 160 may use lazy learning and/ormodel generation to determine relationships between elements ofphysiological data, in combination with or instead of prognostic labels,and ameliorative labels. Where ameliorative process label learner 160determines relationships between elements of physiological data andameliorative labels directly, this may determine relationships betweenprognostic labels and ameliorative labels as well owing to the existenceof relationships determined by prognostic label learner 152.

Referring now to FIG. 8, ameliorative process label learner 160 may beconfigured to perform one or more supervised learning processes, asdescribed above; supervised learning processes may be performed by asupervised learning module 800 executing on diagnostic engine 108 and/oron another computing device in communication with diagnostic engine 108,which may include any hardware or software module. For instance, asupervised learning algorithm may use prognostic labels as inputs,ameliorative labels as outputs, and a scoring function representing adesired form of relationship to be detected between prognostic labelsand ameliorative labels; scoring function may, for instance, seek tomaximize the probability that a given prognostic label and/orcombination of prognostic labels is associated with a given ameliorativelabel and/or combination of ameliorative labels to minimize theprobability that a given prognostic label and/or combination ofprognostic labels is not associated with a given ameliorative labeland/or combination of ameliorative labels. In an embodiment, one or moresupervised machine-learning algorithms may be restricted to a particulardomain; for instance, a supervised machine-learning process may beperformed with respect to a given set of parameters and/or categories ofprognostic labels that have been suspected to be related to a given setof ameliorative labels, for instance because the ameliorative processescorresponding to the set of ameliorative labels are hypothesized orsuspected to have an ameliorative effect on conditions represented bythe prognostic labels, and/or are specified as linked to a medicalspecialty and/or field of medicine covering a particular set ofprognostic labels and/or ameliorative labels. As a non-limiting example,a particular set prognostic labels corresponding to a set ofcardiovascular conditions may be typically treated by cardiologists, anda supervised machine-learning process may be performed to relate thoseprognostic labels to ameliorative labels associated with varioustreatment options, medications, and/or lifestyle changes.

With continued reference to FIG. 8, ameliorative process label learner160 may perform one or more unsupervised machine-learning processes asdescribed above; unsupervised processes may be performed by anunsupervised learning module 804 executing on diagnostic engine 108and/or on another computing device in communication with diagnosticengine 108, which may include any hardware or software module. Forinstance, and without limitation, ameliorative process label learner 160and/or diagnostic engine 108 may perform an unsupervised machinelearning process on second training set 132, which may cluster data ofsecond training set 132 according to detected relationships betweenelements of the second training set 132, including without limitationcorrelations of prognostic labels to each other and correlations ofameliorative labels to each other; such relations may then be combinedwith supervised machine learning results to add new criteria forameliorative process label learner 160 to apply in relating prognosticlabels to ameliorative labels. As a non-limiting, illustrative example,an unsupervised process may determine that a first prognostic label 120correlates closely with a second prognostic label 136, where the firstprognostic label 120 has been linked via supervised learning processesto a given ameliorative label, but the second has not; for instance, thesecond prognostic label 136 may not have been defined as an input forthe supervised learning process, or may pertain to a domain outside of adomain limitation for the supervised learning process. Continuing theexample, a close correlation between first prognostic label 120 andsecond prognostic label 136 may indicate that the second prognosticlabel 136 is also a good match for the ameliorative label; secondprognostic label 136 may be included in a new supervised process toderive a relationship or may be used as a synonym or proxy for the firstprognostic label 120 by ameliorative process label learner 160.Unsupervised processes performed by ameliorative process label learner160 may be subjected to any domain limitations suitable for unsupervisedprocesses performed by prognostic label learner 152 as described above.

Still referring to FIG. 8, diagnostic engine 108 and/or ameliorativeprocess label learner 160 may detect further significant categories ofprognostic labels, relationships of such categories to ameliorativelabels, and/or categories of ameliorative labels using machine-learningprocesses, including without limitation unsupervised machine-learningprocesses as described above; such newly identified categories, as wellas categories entered by experts in free-form fields as described above,may be added to pre-populated lists of categories, lists used toidentify language elements for language learning module, and/or listsused to identify and/or score categories detected in documents, asdescribed above. In an embodiment, as additional data is added to system100, ameliorative process label learner 160 and/or diagnostic engine 108may continuously or iteratively perform unsupervised machine-learningprocesses to detect relationships between different elements of theadded and/or overall data; in an embodiment, this may enable system 100to use detected relationships to discover new correlations between knownbiomarkers, prognostic labels, and/or ameliorative labels and one ormore elements of data in large bodies of data, such as genomic,proteomic, and/or microbiome-related data, enabling future supervisedlearning and/or lazy learning processes to identify relationshipsbetween, e.g., particular clusters of genetic alleles and particularprognostic labels and/or suitable ameliorative labels. Use ofunsupervised learning may greatly enhance the accuracy and detail withwhich system may detect prognostic labels and/or ameliorative labels.

With continued reference to FIG. 8, ameliorative labels may be generatedbased on classification of the at least a prognostic output.Classification as used herein includes pairing or grouping prognosticoutputs as a function of some shared commonality. Prognostic outputs maybe grouped with certain endocrine disorders such as diabetes, metabolicsyndrome, and/or pre-diabetes which may generate an ameliorative labelassociated with a physical exercise recommendation that may includeaerobic exercises such as running, brisk walking, cycling, and/orswimming in an attempt to reduce elevated blood sugar levels in patientswith such endocrine disorders. Prognostic outputs grouped with certainalarm conditions such as chest pains, shortness of breath, cold sweat,and sudden dizziness may generate an ameliorative label associated withmedical tests, diagnostics, and/or procedures for a suspected myocardialinfarction such as an electrocardiogram (EKG), measurement of serumtroponin levels, complete blood count (CBC), chest x-ray,echocardiogram, cardiac CT, cardiac MRI, and/or coronarycatheterization. Ameliorative label may be generated based on groupingssuch as severity of prognostic output. For example, a user who presentswith mild chest pain and some indigestion may be grouped to a categoryof prognostic labels that is serious but not alarming and may generatean ameliorative label that includes a blood test for troponin levels torule out a potential myocardial infarction. A user who presents withcrushing chest pain, tingling down one or both arms, shortness ofbreath, and cold and clammy skin may be grouped into a category of alarmso as to generate an ameliorative label that includes a cardiac CT orcardiac MRI to see if user is suffering from some type of coronaryocclusion and may be a candidate for a possible coronarycatheterization. In yet another non-limiting example, ameliorative labelmay be generated as a function of severity and/or progression ofprognostic output. For example, a prognostic label that includes adiagnosis of hypothyroidism as evidenced by a thyroid stimulating level(TSH) of 6.0 (normal range is 1.4-5.5) may generate an ameliorativelabel that includes 150 mcg per day of iodine supplementation to lowerTSH within normal limits due to mild TSH elevation and/or mildprogression of hypothyroidism. A prognostic output that includes adiagnosis of hypothyroidism as evidenced by a TSH of 15.0 may generatean ameliorative label that includes 300 mcg per day of iodinesupplementation as well as a prescription for a T-4 containingmedication such as Synthroid and a T-3 containing medication such asCytomel due to the more severe progression of hypothyroidism.Classification of at least a prognostic output may include staging of aprognostic label. Staging may include dividing a disease state orcondition into categories on a spectrum of disease progression andsymptomology. For example, a user with a prognostic output thatindicates peri-menopause as evidenced by increasing prevalence of hotflashes may generate an ameliorative label that includes arecommendation for supplementation with black cohosh, while a user witha prognostic output that indicates progression to menopause as evidencedby persistent hot flashes, night sweats, absence of menstruation, dryhair, and fatigue may generate an ameliorative label that containsrecommendations for supplementation with bio-identical hormonereplacement therapy such as estrone (E1), estradiol (E2), estriol (E3),progesterone, testosterone, dehydroepiandrosterone (DHEA), and/orpregnenolone. In yet another non-limiting example, early stage of adisease such as Alzheimer's disease as demonstrated by mild cognitiveimpairment may generate an ameliorative label that includes norecommended medical treatment except for watchful waiting. However,advanced Alzheimer's disease may warrant an ameliorative label thatincludes medical intervention and may require a prescription medication.Ameliorative label may be generated by any of the methodologies asdescribed below in reference to FIG. 19.

Continuing to view FIG. 8, ameliorative process label learner 160 may beconfigured to perform a lazy learning process as a function of thesecond training set 132 and the at least a prognostic output to producethe at least an ameliorative output; a lazy learning process may includeany lazy learning process as described above regarding prognostic labellearner 152. Lazy learning processes may be performed by a lazy learningmodule 808 executing on diagnostic engine 108 and/or on anothercomputing device in communication with diagnostic engine 108, which mayinclude any hardware or software module. Ameliorative output 812 may beprovided to a user output device as described in further detail below.

In an embodiment, and still referring to FIG. 8, ameliorative processlabel learner 160 may generate a plurality of ameliorative labels havingdifferent implications for a particular person. For instance, where aprognostic label indicates that a person has a magnesium deficiency,various dietary choices may be generated as ameliorative labelsassociated with correcting the deficiency, such as ameliorative labelsassociated with consumption of almonds, spinach, and/or dark chocolate,as well as ameliorative labels associated with consumption of magnesiumsupplements. In such a situation, ameliorative process label learner 160and/or diagnostic engine 108 may perform additional processes to resolveambiguity. Processes may include presenting multiple possible results toa medical practitioner, informing the medical practitioner of variousoptions that may be available, and/or that follow-up tests, procedures,or counseling may be required to select an appropriate choice.Alternatively or additionally, processes may include additional machinelearning steps. For instance, ameliorative process label learner 160 mayperform one or more lazy learning processes using a more comprehensiveset of user data to identify a more probably correct result of themultiple results. Results may be presented and/or retained withrankings, for instance to advise a medical professional of the relativeprobabilities of various ameliorative labels being correct or idealchoices for a given person; alternatively or additionally, ameliorativelabels associated with a probability of success or suitability below agiven threshold and/or ameliorative labels contradicting results of theadditional process, may be eliminated. As a non-limiting example, anadditional process may reveal that a person is allergic to tree nuts,and consumption of almonds may be eliminated as an ameliorative label tobe presented.

Continuing to refer to FIG. 8, ameliorative process label learner 160may be designed and configured to generate further training data and/orto generate outputs using longitudinal data 816. As used herein,longitudinal data 816 may include a temporally ordered series of dataconcerning the same person, or the same cohort of persons; for instance,longitudinal data 816 may describe a series of blood samples taken oneday or one month apart over the course of a year. Longitudinal data 816may related to a series of samples tracking response of one or moreelements of physiological data recorded regarding a person undergoingone or more ameliorative processes linked to one or more ameliorativeprocess labels. Ameliorative process label learner 160 may track one ormore elements of physiological data and fit, for instance, a linear,polynomial, and/or splined function to data points; linear, polynomial,or other regression across larger sets of longitudinal data, using, forinstance, any regression process as described above, may be used todetermine a best-fit graph or function for the effect of a givenameliorative process over time on a physiological parameter. Functionsmay be compared to each other to rank ameliorative processes; forinstance, an ameliorative process associated with a steeper slope incurve representing improvement in a physiological data element, and/or ashallower slope in a curve representing a slower decline, may be rankedhigher than an ameliorative process associated with a less steep slopefor an improvement curve or a steeper slope for a curve marking adecline. Ameliorative processes associated with a curve and/or terminaldata point representing a value that does not associate with apreviously detected prognostic label may be ranked higher than one thatis not so associated. Information obtained by analysis of longitudinaldata 816 may be added to ameliorative process database and/or secondtraining set.

Referring again to FIG. 1, system 100 may include a plan generationmodule 168 operating on the at least a server 104. Plan generator module168 may include any suitable hardware or hardware module. In anembodiment, plan generator module 168 is designed and configured togenerate a comprehensive instruction set 172 associated with the userbased on the diagnostic output. In an embodiment, comprehensiveinstruction set 172 is a data structure containing instructions to beprovided to the user to explain the user's current prognostic status, asreflected by one or more prognostic outputs and provide the user with aplan based on the at least an ameliorative output, to achieve that. Inan embodiment, comprehensive instruction set 172 may be generated basedon at least an informed advisor output. Comprehensive instruction set172 may include but is not limited to a program, strategy, summary,recommendation, or any other type of interactive platform that may beconfigured to comprise information associated with the user, anapplicable verified external source, and one or more outputs derivedfrom the analyses performed on the extraction from the user.Comprehensive instruction set 172 may describe to a user a futureprognostic status to aspire to. In an embodiment, plan generation module168 is configured to receive at least an element of user data and filterthe diagnostic output using the at least an element of user data.

Referring now to FIG. 9, an exemplary embodiment of a plan generatormodule 168 is illustrated. Comprehensive instruction set 172 includes atleast a current prognostic descriptor 900 which as used in thisdisclosure is an element of data describing a current prognostic statusbased on at least one prognostic output. Plan generator module 168 mayproduce at least a current prognostic descriptor 900 using at least aprognostic output. In an embodiment, plan generator module 168 mayinclude a label synthesizer 904. Label synthesizer 904 may include anysuitable software or hardware module. In an embodiment, labelsynthesizer 904 may be designed and configured to combine a plurality oflabels in at least a prognostic output together to provide maximallyefficient data presentation. Combination of labels together may includeelimination of duplicate information. For instance, label synthesizer904 and/or at least a server 104 may be designed and configure todetermine a first prognostic label of the at least a prognostic label isa duplicate of a second prognostic label of the at least a prognosticlabel and eliminate the first prognostic label. Determination that afirst prognostic label is a duplicate of a second prognostic label mayinclude determining that the first prognostic label is identical to thesecond prognostic label; for instance, a prognostic label generated fromtest data presented in one biological extraction of at least abiological extraction may be the same as a prognostic label generatedfrom test data presented in a second biological extraction of at least abiological extraction. As a further non-limiting example, a firstprognostic label may be synonymous with a second prognostic label, wheredetection of synonymous labels may be performed, without limitation, bya language processing module 128 as described above.

Continuing to refer to FIG. 9, label synthesizer 904 may groupprognostic labels according to one or more classification systemsrelating the prognostic labels to each other. For instance, plangenerator module 168 and/or label synthesizer 904 may be configured todetermine that a first prognostic label of the at least a prognosticlabel and a second prognostic label of the at least a prognostic labelbelong to a shared category. A shared category may be a category ofconditions or tendencies toward a future condition to which each offirst prognostic label and second prognostic label belongs; as anexample, lactose intolerance and gluten sensitivity may each be examplesof digestive sensitivity, for instance, which may in turn share acategory with food sensitivities, food allergies, digestive disorderssuch as celiac disease and diverticulitis, or the like. Shared categoryand/or categories may be associated with prognostic labels as well. Agiven prognostic label may belong to a plurality of overlappingcategories. Plan generator module 168 may be configured to add acategory label associated with a shared category to comprehensiveinstruction set 172, where addition of the label may include addition ofthe label and/or a datum linked to the label, such as a textual ornarrative description. In an embodiment, relationships betweenprognostic labels and categories may be retrieved from a prognosticlabel classification database 908, for instance by generating a queryusing one or more prognostic labels of at least a prognostic output,entering the query, and receiving one or more categories matching thequery from the prognostic label classification database 908.

Referring now to FIG. 10, an exemplary embodiment of a prognostic labelclassification database 908 is illustrated. Prognostic labelclassification database 908 may be implemented as any database and/ordatastore suitable for use as biological extraction database 300 asdescribed above. One or more database tables in prognostic labelclassification database 908 may include, without limitation, asymptomatic classification table 1000; symptomatic classification table1000 may relate each prognostic label to one or more categories ofsymptoms associated with that prognostic label. As a non-limitingexample, symptomatic classification table 1000 may include recordsindicating that each of lactose intolerance and gluten sensitivityresults in symptoms including gas buildup, bloating, and abdominal pain.One or more database tables in prognostic label classification database908 may include, without limitation, a systemic classification table1004; systemic classification table 1004 may relate each prognosticlabel to one or more systems associated with that prognostic label. As anon-limiting example, systemic classification table 1004 may includerecords indicating each of lactose intolerance and gluten sensitivityaffects the digestive system; two digestive sensitivities linked toallergic or other immune responses may additionally be linked insystemic classification table 1004 to the immune system. One or moredatabase tables in prognostic label classification database 908 mayinclude, without limitation, a body part classification table 1008; bodypart classification table 1008 may relate each prognostic label to oneor more body parts associated with that prognostic label. As anon-limiting example, body part classification table 1008 may includerecords indicating each of psoriasis and rosacea affects the skin of aperson. One or more database tables in prognostic label classificationdatabase 908 may include, without limitation, a causal classificationtable 1112; causal classification table 1112 may relate each prognosticlabel to one or more causes associated with that prognostic label. As anon-limiting example, causal classification table 1112 may includerecords indicating each of type 2 diabetes and hypertension may haveobesity as a cause. The above-described tables, and entries therein, areprovided solely for exemplary purposes. Persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of variousadditional examples for tables and/or relationships that may be includedor recorded in prognostic classification table consistently with thisdisclosure.

Referring again to FIG. 9, plan generator module 168 may be configuredto generate current prognostic descriptor 900 by converting one or moreprognostic labels into narrative language. As a non-limiting example,plan generator module 168 may include a narrative language unit 912,which may be configured to determine an element of narrative languageassociated with at least a prognostic label and include the element ofnarrative language in current prognostic label descriptor. Narrativelanguage unit 912 may implement this, without limitation, by using alanguage processing module 128 to detect one or more associationsbetween prognostic labels, or lists of prognostic labels, and phrasesand/or statements of narrative language. Alternatively or additionally,narrative language unit 912 may retrieve one or more elements ofnarrative language from a narrative language database 916, which maycontain one or more tables associating prognostic labels and/or groupsof prognostic labels with words, sentences, and/or phrases of narrativelanguage. One or more elements of narrative language may be included incomprehensive instruction set 172, for instance for display to a user astext describing a current prognostic status of the user. Currentprognostic descriptor 900 may further include one or more images; one ormore images may be retrieved by plan generator module 168 from an imagedatabase 920, which may contain one or more tables associatingprognostic labels, groups of prognostic labels, current prognosticdescriptors 1000, or the like with one or more images.

With continued reference to FIG. 9, comprehensive instruction set 172may include one or more follow-up suggestions, which may include,without limitation, suggestions for acquisition of an additionalbiological extraction; in an embodiment, additional biologicalextraction may be provided to diagnostic engine 108, which may triggerrepetition of one or more processes as described above, includingwithout limitation generation of prognostic output, refinement orelimination of ambiguous prognostic labels of prognostic output,generation of ameliorative output, and/or refinement or elimination ofambiguous ameliorative labels of ameliorative output. For instance,where a pegboard test result suggests possible diagnoses of Parkinson'sdisease, Huntington's disease, ALS, and MS as described above, follow-upsuggestions may include suggestions to perform endocrinal tests, genetictests, and/or electromyographic tests; results of such tests mayeliminate one or more of the possible diagnoses, such that asubsequently displayed output only lists conditions that have not beeneliminated by the follow-up test. Follow-up tests may include anyreceipt of any biological extraction as described above.

With continued reference to FIG. 9, comprehensive instruction set mayinclude one or more elements of contextual information, includingwithout limitation any patient medical history such as current labresults, a current reason for visiting a medical professional, currentstatus of one or more currently implemented treatment plans,biographical information concerning the patient, and the like. One ormore elements of contextual information may include goals a patientwishes to achieve with a medical visit or session, and/or as result ofinteraction with diagnostic engine 108. Contextual information mayinclude one or more questions a patient wishes to have answered in amedical visit and/or session, and/or as a result of interaction withdiagnostic engine 108. Contextual information may include one or morequestions to ask a patient. Persons skilled in the art, upon reviewingthe entirety of this disclosure, will be aware of various forms ofcontextual information that may be included, consistently with thisdisclosure.

With continued reference to FIG. 9, comprehensive instruction set 172may include at least a future prognostic descriptor 924. As used herein,a future prognostic descriptor 924 is an element of data describing afuture prognostic status based on at least one prognostic output, whichmay include without limitation a desired further prognostic status. Inan embodiment, future prognostic descriptor 924 may include any elementsuitable for inclusion in current prognostic descriptor 900. Futureprognostic descriptor 924 may be generated using any processes, modules,and/or components suitable for generation of current prognosticdescriptor 900 as described above.

Still referring to FIG.9, comprehensive instruction set 172 includes atleast an ameliorative process descriptor 1028, which as defined in thisdisclosure an element of data describing one or more ameliorativeprocesses to be followed based on at least one ameliorative output; atleast an ameliorative process descriptor 1028 may include descriptorsfor ameliorative processes usable to achieve future prognosticdescriptor 924. Plan generator module 168 may produce at least anameliorative process descriptor 1028 using at least a prognostic output.In an embodiment, label synthesizer 904 may be designed and configuredto combine a plurality of labels in at least an ameliorative outputtogether to provide maximally efficient data presentation. Combinationof labels together may include elimination of duplicate information. Forinstance, label synthesizer 904 and/or at least a server 104 may bedesigned and configure to determine a first ameliorative label of the atleast an ameliorative label is a duplicate of a second ameliorativelabel of the at least an ameliorative label and eliminate the firstameliorative label. Determination that a first ameliorative label is aduplicate of a second ameliorative label may include determining thatthe first ameliorative label is identical to the second ameliorativelabel; for instance, a ameliorative label generated from test datapresented in one biological extraction of at least a biologicalextraction may be the same as a ameliorative label generated from testdata presented in a second biological extraction of at least abiological extraction. As a further non-limiting example, a firstameliorative label may be synonymous with a second ameliorative label,where detection of synonymous labels may be performed, withoutlimitation, by a language processing module 128 as described above.

Continuing to refer to FIG. 9, label synthesizer 904 may groupameliorative labels according to one or more classification systemsrelating the ameliorative labels to each other. For instance, plangenerator module 168 and/or label synthesizer 904 may be configured todetermine that a first ameliorative label of the at least anameliorative label and a second ameliorative label of the at least anameliorative label belong to a shared category. A shared category may bea category of conditions or tendencies toward a future condition towhich each of first ameliorative label and second ameliorative labelbelongs; as an example, lactose intolerance and gluten sensitivity mayeach be examples of digestive sensitivity, for instance, which may inturn share a category with food sensitivities, food allergies, digestivedisorders such as celiac disease and diverticulitis, or the like. Sharedcategory and/or categories may be associated with ameliorative labels aswell. A given ameliorative label may belong to a plurality ofoverlapping categories. Plan generator module 168 may be configured toadd a category label associated with a shared category to comprehensiveinstruction set 172, where addition of the label may include addition ofthe label and/or a datum linked to the label, such as a textual ornarrative description. In an embodiment, relationships betweenameliorative labels and categories may be retrieved from an ameliorativelabel classification database 932, for instance by generating a queryusing one or more ameliorative labels of at least an ameliorativeoutput, entering the query, and receiving one or more categoriesmatching the query from the ameliorative label classification database932.

Referring now to FIG. 11, an exemplary embodiment of an ameliorativelabel classification database 932 is illustrated. Ameliorative labelclassification database 932 may be implemented as any database and/ordatastore suitable for use as biological extraction database 300 asdescribed above. One or more database tables in ameliorative labelclassification database 932 may include, without limitation, anintervention category table 1100; intervention 1200 may relate eachameliorative label to one or more categories associated with thatameliorative label. As a non-limiting example, intervention categorytable 1100 may include records indicating that each of a plan to consumea given quantity of almonds and a plan to consume less meat maps to acategory of nutritional instruction, while a plan to jog for 30 minutesper day maps to a category of activity. One or more database tables inameliorative label classification database 932 may include, withoutlimitation, a nutrition category table 1104; nutrition category table1104 may relate each ameliorative label pertaining to nutrition to oneor more categories associated with that ameliorative label. As anon-limiting example, nutrition category table 1104 may include recordsindicating that each of a plan to consume more almonds and a plan toconsume more walnuts qualifies as a plan to consume more nuts, as wellas a plan to consume more protein. One or more database tables inameliorative label classification database 932 may include, withoutlimitation, an action category table 1108; action category table 1108may relate each ameliorative label pertaining to an action to one ormore categories associated with that ameliorative label. As anon-limiting example, action category table 1108 may include recordsindicating that each of a plan jog for 30 minutes a day and a plan toperform a certain number of sit-ups per day qualifies as an exerciseplan. One or more database tables in ameliorative label classificationdatabase 932 may include, without limitation, a medication categorytable 1112; medication category table 1112 may relate each ameliorativelabel associated with a medication to one or more categories associatedwith that ameliorative label. As a non-limiting example, medicationcategory table 1112 may include records indicating that each of a planto take an antihistamine and a plan to take an anti-inflammatory steroidbelongs to a category of allergy medications. One or more databasetables in ameliorative label classification database 932 may include,without limitation, a supplement category table 1116; supplementcategory table 1116 may relate each ameliorative label pertaining to asupplement to one or more categories associated with that ameliorativelabel. As a non-limiting example, supplement category table 1116 mayinclude records indicating that each of a plan to consume a calciumsupplement and a plan to consume a vitamin D supplement corresponds to acategory of supplements to aid in bone density. Ameliorative labels maybe mapped to each of nutrition category table 1104, action categorytable 1108, supplement category table 1116, and medication categorytable 1112 using intervention category table 1100. The above-describedtables, and entries therein, are provided solely for exemplary purposes.Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various additional examples for tablesand/or relationships that may be included or recorded in ameliorativeclassification table consistently with this disclosure.

Referring again to FIG. 9, plan generator module 168 may be configuredto generate ameliorative process descriptor 1028 by converting one ormore ameliorative labels into narrative language. As a non-limitingexample, plan generator module 168 may include a narrative language unit912, which may be configured to determine an element of narrativelanguage associated with at least an ameliorative label and include theelement of narrative language in current ameliorative label descriptor.Narrative language unit 912 may implement this, without limitation, byusing a language processing module 128 to detect one or moreassociations between ameliorative labels, or lists of ameliorativelabels, and phrases and/or statements of narrative language.Alternatively or additionally, narrative language unit 912 may retrieveone or more elements of narrative language from narrative languagedatabase 916, which may contain one or more tables associatingameliorative labels and/or groups of ameliorative labels with words,sentences, and/or phrases of narrative language. One or more elements ofnarrative language may be included in comprehensive instruction set 172,for instance for display to a user as text describing a currentameliorative status of the user. Ameliorative process descriptor 1028may further include one or more images; one or more images may beretrieved by plan generator module 168 from an image database 920, whichmay contain one or more tables associating ameliorative labels, groupsof ameliorative labels, ameliorative process descriptors 1028, or thelike with one or more images.

Referring now to FIG. 12, and exemplary embodiment of a narrativelanguage database 916 is illustrated. Narrative language database 916may be implemented as any database and/or datastore suitable for use asbiological extraction database 300 as described above. One or moredatabase tables in narrative language database 916 may include, withoutlimitation, a prognostic description table 1200, which may linkprognostic labels to narrative descriptions associated with prognosticlabels. One or more database tables in narrative language database 916may include, without limitation, an ameliorative description table 1204,which may link ameliorative process labels to narrative descriptionsassociated with ameliorative process labels. One or more database tablesin narrative language database 916 may include, without limitation, acombined description table 1208, which may link combinations ofprognostic labels and ameliorative labels to narrative descriptionsassociated with the combinations. One or more database tables innarrative language database 916 may include, without limitation, aparagraph template table 1212, which may contain one or more templatesof paragraphs, pages, reports, or the like into which images and text,such as images obtained from image database 920 and text obtained fromprognostic description table 1200, ameliorative description table 1204,and combined description table 1208 may be inserted. Tables in narrativedescription table 1016 may be populated, as a non-limiting example,using submissions from experts, which may be collected according to anyprocesses described above. Persons skilled in the art, upon reviewingthe entirety of this disclosure, will be aware of various way sin whichentries in narrative description table 1016 may be categorized and/ororganized.

Referring now to FIG. 13, an exemplary embodiment of an image database920 is illustrated. Image database 920 may be implemented as anydatabase and/or datastore suitable for use as biological extractiondatabase 300 as described above. One or more database tables in imagedatabase 102 may include, without limitation, a prognostic image table1300, which may link prognostic labels to images associated withprognostic labels. One or more database tables in image database 920 mayinclude, without limitation, an ameliorative image table 1304, which maylink ameliorative process labels to images associated with ameliorativeprocess labels. One or more database tables in image database 920 mayinclude, without limitation, a combined description table 1408, whichmay link combinations of prognostic labels and ameliorative labels toimages associated with the combinations. One or more database tables inimage database 102 may include, without limitation, a prognostic videotable 1312, which may link prognostic labels to videos associated withprognostic labels. One or more database tables in image database 920 mayinclude, without limitation, an ameliorative video table 1316, which maylink ameliorative process labels to videos associated with ameliorativeprocess labels. One or more database tables in image database 920 mayinclude, without limitation, a combined video table 1320, which may linkcombinations of prognostic labels and ameliorative labels to videosassociated with the combinations. Tables in image database 920 may bepopulated, without limitation, by submissions by experts, which may beprovided according to any process or process steps described in thisdisclosure for collection of expert submissions.

Referring again to FIG. 9, plan generator module 168 may be configuredto receive at least an element of user data and filter diagnostic outputusing the at least an element of user data. At least an element of userdata, as used herein, is any element of data describing the user, userneeds, and/or user preferences. At least an element of user data mayinclude a constitutional restriction. At least a constitutionalrestriction may include any health-based reason that a user may beunable to engage in a given ameliorative process; at least aconstitutional restriction may include any counter-indication asdescribed above, including an injury, a diagnosis of somethingpreventing use of one or more ameliorative processes, an allergy orfood-sensitivity issue, a medication that is counter-indicated, or thelike. At least an element of user data may include at least a userpreference. At least a user preference may include, without limitation,any preference to engage in or eschew any ameliorative process and/orother potential elements of a comprehensive instruction set 172,including religious preferences such as forbidden foods, medicalinterventions, exercise routines, or the like.

Referring to FIG. 14, an exemplary embodiment of a user database 936 isillustrated. User database 936 may be implemented as any database and/ordatastore suitable for use as biological extraction database 300 asdescribed above. One or more database tables in user database 936 mayinclude, without limitation, a constitution restriction table 1500; atleast a constitutional restriction may be linked to a given user and/oruser identifier in a constitutional restriction table 1400. One or moredatabase tables in user database 936 may include, without limitation, auser preference table 1404; at least a user preference may be linked toa given user and/or user identifier in a user preference table 1404.

Referring again to FIG. 1, system 100 may include a client-interfacemodule 176. Client-interface module 176 may include any suitablehardware or software module. Client-interface module 176 may designedand configured to transmit comprehensive instruction set 172 to at leasta user client device 180 associated with the user. A user client device180 may include, without limitation, a display in communication withdiagnostic engine 108; display may include any display as describedbelow in reference to FIG. 19. A user client device 180 may include anaddition computing device, such as a mobile device, laptop, desktopcomputer, or the like; as a non-limiting example, the user client device180 may be a computer and/or workstation operated by a medicalprofessional. Output may be displayed on at least a user client device180 using an output graphical user interface; output graphical userinterface may display at least a current prognostic descriptor 900, atleast a future prognostic descriptor 924, and/or at least anameliorative process descriptor 928.

With continued reference to FIG. 1, system 100 includes at least anadvisory module executing on the at least a server 104. At least anadvisory module 184 may include any suitable hardware or softwaremodule. In an embodiment, at least an advisory module 184 is designedand configured to generate at least an advisory output as a function ofthe comprehensive instruction set 172 and may transmit the advisoryoutput to at least an advisor client device 188. At least an advisorclient device 188 may include any device suitable for use as a userclient device 180 as described above. At least an advisor client device188 may operate on system 100 and may be a user client device 180 asdescribed above; that is, at least an advisory output may be output tothe user client device 180. Alternatively or additionally, at least anadvisor client device 188 may be operated by an informed advisor,defined for the purposes of this disclosure as any person besides theuser who has access to information useable to aid user in interactionwith artificial intelligence advisory system. An informed advisor mayinclude, without limitation, a medical professional such as a doctor,nurse, nurse practitioner, functional medicine practitioner, anyprofessional with a career in medicine, nutrition, genetics, fitness,life sciences, insurance, and/or any other applicable industry that maycontribute information and data to system 100 regarding medical needs.An informed advisor may include a spiritual or philosophical advisor,such as a religious leader, pastor, imam, rabbi, or the like. Aninformed advisor may include a physical fitness advisor, such as withoutlimitation a personal trainer, instructor in yoga or martial arts,sports coach, or the like.

Referring now to FIG. 15, an exemplary embodiment of an advisory module184 is illustrated. Advisory module 184 may be configured to generate anadvisor instruction set 1600 as a function of the diagnostic output.Advisory instruction set 1500 may contain any element suitable forinclusion in comprehensive instruction set 172; advisory instruction set1500 and/or any element thereof may be generated using any processsuitable for generation of comprehensive instruction set 172. Advisoryinstruction set 1500 may include one or more specialized instructions1504; specialized instructions, as used herein, are instructions thecontents of which are selected for display to a particular informedadvisor. Selection of instructions for a particular informed advisor maybe obtained, without limitation, from information concerning theparticular informed advisor, which may be retrieved from a user database936 or the like. As a non-limiting example, where an informed advisor isa doctor, specialized instruction 1504 may include data from biologicalextraction as described above; specialized instruction may include oneor more medical records of user, which may, as a non-limiting example,be downloaded or otherwise received from an external database containingmedical records and/or a database (not shown) operating on at least aserver 104. As a further non-limiting example medical data relevant tofitness, such as orthopedic reports, may be provided to an informedadvisor whose role is as a fitness instructor, coach, or the like.

In an embodiment, and continuing to refer to FIG. 15, advisory module184 may be configured to receive at least an advisory input from theadvisor client device 188. At least an advisory input may include anyinformation provided by an informed advisor via advisor client device188. Advisory input may include medical information and/or advice.Advisory input may include user data, including user habits,preferences, religious affiliations, constitutional restrictions, or thelike. Advisory input may include spiritual and/or religious advice.Advisory input may include user-specific diagnostic information.Advisory input may be provided to user client device 180; alternativelyor additionally, advisory input may be fed back into system 100,including without limitation insertion into user database 936, inclusionin or use to update diagnostic engine 108, for instance by augmentingmachine-learning models and/or modifying machine-learning outputs via alazy-learning protocol or the like as described above.

With continued reference to FIG. 15, advisory module 184 may include anartificial intelligence advisor 1508 configured to perform a usertextual conversation with the user client device 180. Artificialintelligence advisor 1508 may provide output to advisor client device188 and/or user client device 180. Artificial intelligence advisor 1508may receive inputs from advisor client device 188 and/or user clientdevice 180. Inputs and/or outputs may be exchanged using messagingservices and/or protocols, including without limitation any instantmessaging protocols. Persons skilled in the art, up reviewing theentirety of this disclosure, will be aware of a multiplicity ofcommunication protocols that may be employed to exchange text messagesas described herein. Text messages may be provided in textual formand/or as audio files using, without limitation, speech-to-text and/ortext-to-speech algorithms.

With continued reference to FIG. 15, advisory module 184 may output,with advisory output, a textual entry field 1512. Textual entry field1512 may include a searchable input field that allows entry of a searchterm such as a word or phrase to be entered by a user such as aninformed advisor. In an embodiment, textual entry field 1512 may allowfor entry of a search term to be matched with labels contained withinthe at least at diagnostic output. For example, an informed advisor suchas a medical professional may enter into a search term a results of afasting glucose test after receiving at least a diagnostic output ofdiabetes. In such an instance, user such as an informed advisor may beable to search multiple results such as fasting glucose test levelsrecorded over a certain period of time such as several years and/ormonths. In yet another non-limiting example, an informed advisor such asa fitness professional may search for user's most recent exercise logand/or nutrition records. In yet another non-limiting example, aninformed advisor such as a nurse practitioner may enter information intotextual entry field 1512 to search for information pertaining to user'smedication history after receiving at least a diagnostic output of acutekidney injury. In an embodiment, textual entry field 1512 may allow auser such as an informed advisor to navigate different areas of advisoryoutput. For example, an informed advisor may utilize textual entry field1512 to navigate to different locations such as a table of contents, andor sections organized into different categories as described in moredetail below.

With continued reference to FIG. 15, advisory module 184 may include inan advisory output a category field 1516. Category field 1516 mayinclude a textual field that contains advisory output organized intocategories. Category, as used herein, is any breakdown of advisoryoutput by shared characteristics. Categories may include for example,breakdown by informed advisor type. For example, informed advisors maybe categorized into categories of expertise such as spiritualprofessionals, nutrition professionals, fitness professionals and thelike. Categories may include sub-categories of specialties such as forexample functional medicine informed advisors may be organized intosub-categories based on body system they may be treating. This couldinclude sub-categories such as dermatology specialists, Genito-urologyspecialists, gastroenterology specialists, neurology specialists and thelike. Categories may include a breakdown by time such as chronologicalorder and/or reverse chronological order. Categories may be modifiedand/or organized into test results such as for example all completeblood counts that a user has ever had performed may be located in onecategory, and all CT scans that a user has had performed may be locatedin another category. Categories may include a breakdown by relevance,such as highly relevant test results and/or test results that areoutside normal limits.

With continued reference to FIG. 15, advisory module 184 may include inan advisory output a relevance field 1520. Relevance field 1520 as usedherein is a textual field that contains advisory output informationlabeled as being relevant. Relevance, as used herein, is any informationcontained within advisory output that is closely connected and/orrelated to diagnostic output. Relevance may include information thatwould be of interest to a particular category of informed advisor. Forexample, an informed advisor such as an ophthalmologist may deeminformation contained within at least an advisory output such as ameasurement of a user's intra-ocular pressure to be of relevance, whilean advisory output containing information summarizing a user's lastappointment with a podiatrist to not be of relevance. In yet anothernon-limiting example, an informed advisor such as a fitness professionalmay deem information contained within an advisory output such as asummary of a user's last appointment with an orthopedic doctor to berelevant while a summary of a user's last colonoscopy may not berelevant. In an embodiment, relevance may be viewed on a continuum.Information contained within at least an advisory output that directlyrelates to an informed advisor and is of high probative value to aninformed advisor may be highly relevant. For example, a nutritionist maydeem a journal of a user's eating habits as highly relevant. In yetanother non-limiting example, a spiritual professional may deem asummary of a user's church patterns as highly relevant. Information thatis related to an informed advisor but does not directly affect aninformed advisor may be moderately relevant. For example, adermatologist may deem information pertaining to a user's last physicalexam with an internal medicine doctor to be moderately relevant. In yetanother non-limiting example, an endocrinologist may deem informationpertaining to a user's last appointment with a podiatrist to bemoderately relevant for a user diagnosed with diabetes. Information thatis not related to an informed advisor and does not affect an informedadvisor may be of low relevance. For example, a trauma surgeon may deeminformation about a user's last dental cleaning to be of low relevance.In yet another non-limiting example, a cardiologist may deem informationabout a user's last bone density scan to be of low relevance. In anembodiment, user such as informed advisor may use textual entry field1512 to navigate advisory output to find information that is relevant.In an embodiment, information contained within at least an advisoryoutput may be marked as relevant such as by another informed advisor.For example, a functional medicine doctor may mark an elevated fastingblood glucose level as relevant before transmitting such a result to anutrition professional.

In an embodiment, and still referring to FIG. 15, a relevance field 1520may include an image, link, or other visual element that an informedadvisor may select or otherwise interact with to expand or contract aportion of advisory output; for instance, relevance field 1520 mayinclude a symbol next to or on a section heading that can cause acorresponding section of text to display when activated a first time anddisappear when activated a second time. As a result, an informed advisormay be presented initially with some text visible and other text notvisible; initial presentation may hide all text but section headers.Alternatively or additionally, where informed advisor belongs to aparticular category of informed advisor and/or has a profile in, forinstance, advisory database 1524 indicating categories of interest tothe informed advisor, sections of text and/or images related to suchcategories may initially display while other sections do not displayunless a relevance field 1520 corresponding to such sections is selectedby the informed advisor.

With continued reference to FIG. 15, advisory module 184 containsadvisory database 1524. Advisory database 1524 may be implemented as anydatabase and/or datastore suitable for use as an advisory database. Anexemplary embodiment of an advisory database 1524 is provided below inFIG. 17.

Referring now to FIG. 16, an exemplary embodiment of an artificialintelligence advisor 1508 is illustrated. Artificial intelligenceadvisor 1508 may include a user communication learner 1600. Usercommunication learner 1600 may be any form of machine-learning learneras described above, implementing any form of language processing and/ormachine learning. In an embodiment, user communication learner 1600 mayinclude a general learner 1604; general learner 1604 may be a learnerthat derives relationships between user inputs and correct outputs usinga training set that includes, without limitation, a corpus of previousconversations. Corpus of previous conversations may be logged by atleast a server 104 as conversations take place; user feedback, and/orone or more functions indicating degree of success of a conversation maybe used to differentiate between positive input-output pairs to use fortraining and negative input-output pairs not to use for training.Outputs may include textual strings and/or outputs from any databases,modules, and/or learners as described in this disclosure, includingwithout limitation prognostic labels, prognostic descriptors,ameliorative labels, ameliorative descriptors, user information, or thelike; for instance, general learner 1604 may determine that some inputsoptimally map to textual response outputs, while other inputs map tooutputs created by retrieval of module and/or database outputs, such asretrieval of prognostic descriptors, ameliorative descriptors, or thelike. User communication learner may include a user-specific learner1608, which may generate one or more modules that learn input-outputpairs pertaining to communication with a particular user; a userspecific learner 1708 may initially use input-output pairs establishedby general learner 1604 and may modify such pairs to match optimalconversation with the particular user by iteratively minimizing an errorfunction.

Still referring to FIG. 16, general learner 1604 and/or user-specificlearner 1608 may initialize, prior to training, using one or more recordretrieved from a default response database 1612. Default responsedatabase 1612 may link inputs to outputs according to initialrelationships entered by users, including without limitation experts asdescribed above, and/or as created by a previous instance or version ofgeneral learner 1604 and/or user-specific learner 1608. Default responsedatabase 1612 may periodically be updated with information from newlygenerated instances of general learner 1604 and/or user-specific learner1608. Inputs received by artificial intelligence advisor 1508 may bemapped to canonical and/or representative inputs by synonym detection asperformed, for instance, by a language processing module 128; languageprocessing module 128 may be involved in textual analysis and/orgeneration of text at any other point in machine-learning and/orcommunication processes undergone by artificial intelligence advisor1508.

Referring now to FIG. 17, an exemplary embodiment of advisory database1524 is illustrated. One or more database tables in advisory database1524 may link to data surrounding an informed advisor. Advisory database1524 may include one or more database tables categorized by expertise ofinformed advisor. One or more database tables in advisory database 1524may include, without limitation, an artificial intelligence informedadvisors table 1704, which may contain any and all informationpertaining to artificial intelligence informed advisors. One or moredatabase tables in advisory database 1524 may include, withoutlimitation, a spiritual professional informed advisors table 1708, whichmay contain any and all information pertaining to spiritual professionalinformed advisors. Spiritual professional informed advisors may includespiritual professionals who may participate in cultivating spiritualitythrough exercise of practices such as prayer, meditation, breath work,energy work, and the like. One or more database tables in advisorydatabase 1524 may include, without limitation, a nutrition professionalinformed advisors table 1712, which may include any and all informationpertaining to nutritional informed advisors. Nutritional informedadvisors may include dieticians, chefs, and nutritionists who may offerexpertise around a user's diet and nutrition state and supplementation.One or more database tables in advisory database 1524 may include,without limitation a fitness professional informed advisors table 1716,which may include any and all information pertaining to fitnessprofessional informed advisors. Fitness professional informed advisorsmay examine the fitness state of a user and may include personaltrainers, coaches, group exercise instructors, and the like. One or moredatabase tables in advisory database 1524 may include, withoutlimitation a functional medicine informed advisors table 1720, which mayinclude any and all information pertaining to functional medicineinformed advisors. Functional medicine informed advisors may includedoctors, nurses, physician assistants, nurse practitioners and othermembers of the health care team. One or more database tables in advisorydatabase 1524 may include, without limitation a friends and familyinformed advisors table 1724, which may include any and all informationpertaining to friends and family informed advisors. Friends and familyinformed advisors may include friends and family members of a user whomay create a positive community of support for a user. One or moredatabase tables in advisory database 1524 may include, withoutlimitation an electronic behavior coach informed advisor table 1728,which may include any and all information pertaining to electronicbehavior coach informed advisors. Electronic behavior coach informedadvisors may assist a user in achieving certain results such asmodifying behaviors to achieve a result such as assisting in additionrecovery and/or changing a user's eating habits to lose weight. One ormore database tables in advisory database 1524 may include withoutlimitation a miscellaneous informed advisor table 1732, which mayinclude any and all information pertaining to miscellaneous informedadvisors. Miscellaneous informed advisors may include any informedadvisors who do not fit into one of the categories such as for exampleinsurance coverage informed advisors. Miscellaneous informed advisortable 1732 may also contain miscellaneous information pertaining toinformed advisors such as a user's preference for informed advisors in acertain geographical location and/or other preferences for informedadvisors.

Referring now to FIG. 18, an exemplary embodiment of a default responsedatabase 1612 is illustrated. Default response database 1612 may beimplemented as any database and/or datastore suitable for use asbiological extraction database 300 as described above. One or moredatabase tables in default response database 1612 may include, withoutlimitation, an input/output table 1800, which may link default inputs todefault outputs. Default response database 1612 may include a user table1804, which may, for instance, map users and/or a user client device 180to particular user-specific learners and/or past conversations. Defaultresponse database 1612 may include a user preference table 1808 listingpreferred modes of address, turns of phrase, or other user-specificcommunication preferences. Default response database 1612 may include ageneral preference table 1812, which may track, for instance,output-input pairings associated with greater degrees of usersatisfaction.

Referring again to FIG. 16, artificial intelligence advisor may includea consultation initiator 1616 configured to detect a consultation eventin a user textual conversation and initiate a consultation with aninformed advisor as a function of the consultation event. A consultationevent, as used herein, is a situation where an informed advisor isneeded to address a user's situation or concerns, such as when a usershould be consulting with a doctor regarding an apparent medicalemergency or new condition, or with an advisor who can lend emotionalsupport when particularly distraught. Detection may be performed,without limitation, by matching an input and/or set of inputs to anoutput that constitutes an action of initiating a consultation; such apairing of an input and/or input set may be learned using a machinelearning process, for instance via general learner and/or user specificlearner 1608. In the latter case, information concerning a particularuser's physical or emotional needs or condition may be a part of thetraining set used to generate the input/input set to consultation eventpairing; for instance, a user with a history of heart disease maytrigger consultation events upon any inputs describing shortness ofbreath, chest discomfort, arrhythmia, or the like. Initiation ofconsultation may include transmitting a message to an advisor clientdevice 188 associated with an appropriate informed advisor, such aswithout limitation transmission of information regarding a potentialmedical emergency to a doctor able to assist in treating the emergency.Initiation of consultation may alternatively or additionally includeproviding an output to the user informing the user that a consultationwith an informed advisor, who may be specified by name or role, isadvisable.

Referring now to FIG. 19, an exemplary embodiment of a method 1900 ofutilizing diagnostics for informed vibrant constitutional guidance isillustrated. At step 1905, a diagnostic engine 108 receives trainingdata. Training data includes a first training set 112 including aplurality of first data entries, each first data entry of the firsttraining set 112 including at least an element of physiological statedata 116 and at least a correlated prognostic label. In an embodiment,receiving the first training set 112 may include associating the atleast an element of physiological state data 116 with at least acategory from a list of significant categories of physiological statedata 116. Receiving the list of significant categories from at least anexpert. Receiving the first training set 112 may include associating theat least correlated first prognostic label 120 with at least a categoryfrom a list of significant categories of prognostic labels.

With continued reference to FIG. 19, training data includes a secondtraining set 132 including a plurality of second data entries, eachsecond data entry of the first training set 112 including at least aprognostic label and at least a correlated ameliorative process label140. In an embodiment, receiving second training set 132 may includeassociating at least second prognostic label 136 with at least acategory from a list of significant categories of prognostic labels.Receiving second training set 132 may include associating at leastcorrelated ameliorative process label 140 with at least a category froma list of significant categories of ameliorative process labels 140.

With continued reference to FIG. 19, receiving the second training set132 further comprises receiving at least a document describing at leasta medical history and extracting at least a second data entry of theplurality of second data entries from the at least a document.

With continued reference to FIG. 19, receiving the second training set132 further comprises receiving from at least an expect, at least asecond data entry of the plurality of second data entries.

With continued reference to FIG. 19, at step 1910 diagnostic engine 108operating on the at least a server 104 receives at least a biologicalextraction from a user. Receiving at least a biological extraction froma user may include receiving at a physically extracted sample. This mayinclude for example, receiving a blood sample of a user, an endocrinalsample, a DNA sample, an RNA sample and the like. Receiving at least abiological extraction may be implemented, without limitation, asdescribed above in reference to FIGS. 1-18.

With continued reference to FIG. 19, at step 1915 diagnostic engine 108operating on the at least a server 104 generates a diagnostic outputbased on the at least a biological extraction. Diagnostic outputincludes at least a prognostic label and at least an ameliorativeprocess label. Prognostic label may be generated by prognostic labellearner 152 operating on diagnostic engine 108. Prognostic label may begenerated as a function of the first training set and at least abiological extraction. Prognostic output may be generated by a lazylearning as a function of the first training set and the at least abiological extraction.

Prognostic label may be generated by at least a first machine-learningmodel 156 relating physiological state data to prognostic labels. Forexample, one or more models may determine relationships betweenphysiological state data and prognostic labels. Relationships mayinclude linear regression models and may be modeled around relationshipsbetween physiological state data and current prognostic labels.Prognostic output may be generated as a function of a classification ofthe prognostic label. Prognostic labels may be categorized intodifferent pairings and/or groupings as described above in reference toFIGS. 1-18. Machine-learning may examine relationships betweenphysiological state data and prognostic labels. Machine-learningalgorithms may include any and all algorithms as performed by anymodules as described in this disclosure, including without limitationalgorithms described above regarding prognostic label learner 152 and/orlanguage processing module 128. For example, machine-learning mayexamine relationships between 25-hydroxy Vitamin D levels and currentdiagnosis of seasonal affective disorder (SAD). Machine-learning mayexamine relationships between physiological state data such as aprecursor condition and subsequent development of a condition, such asblood tests that are positive for varicella zoster virus (chicken pox)and subsequent diagnosis of herpes zoster, commonly known as shingles.Machine-learning models may examine relationships between currentpopulation of an individual's internal microbiome such as presence ofcommensal Clostridioides Difficile (C. difficile) and later developmentand diagnosis of pathogenic C. difficile infection. Machine-learningmodels may examine relationships between current population of anindividual's external microbiome such as presence of commensalStaphylococcus Aureus species and later development and diagnosis ofpathogenic infections such as Methicillin-Resistant Staphylococcusaureus (MRSA). Machine-learning models may examine relationships betweencurrent physiological state and future development and diagnosis of adisease or condition such as the presence of Breast Cancer Gene 1(BRCA1) and/or Breast Cancer Gene 2 (BRCA2) and later development anddiagnosis of breast cancer and/or other cancers such as stomach cancer,pancreatic cancer, prostate cancer, and/or colon cancer.Machine-learning models may examine relationships between physiologicalstate data and diagnosed conditions such as triglyceride level, fastingglucose level, HDL cholesterol level, waist circumference, and/orsystolic blood pressure and later development and diagnosis of metabolicsyndrome. Machine-learning models may examine precursor state and rateof progression to diagnosis, such as appearance of drusen underneath theretina and/or angiography and rate of progression to diagnosis ofmacular degeneration. Machine-learning models may examine age of user atprecursor state and rate of progression to diagnosis, such as appearanceof drusen in a 20-year-old and subsequent age of diagnosis of maculardegeneration as compared to appearance of drusen in an 85-year-old andsubsequent age of diagnosis of macular degeneration. Machine-learningmodels may examine relationships between a plurality of prognosticlabels and root cause analysis, such as for example, prognostic labelsthat include presence of joint pain, limited mobility, elevated fastingglucose levels, and high body mass index (BMI) may indicate possiblelinkages to a root cause prognostic label of obesity. In yet anothernon-limiting example, a plurality of prognostic labels such as presenceof Acanthosis nigricans, elevated fasting blood sugar (blood glucoselevel greater than 100 mg/dL), endometrial hyperplasia, elevated bloodpressure (greater than 130 mmHg systolic and/or greater than 80 mmHgdiastolic), elevated total cholesterol levels (greater than 200 mg/dL),and elevated triglycerides (greater than 200 mg/dL) may indicatepossible linkages to a root cause prognostic label of Polycystic OvarianSyndrome (PCOS). Machine-learning models may examine correlations andrelationships between physiological state and overall mortality such asfor example measurement of telomeric DNA length and mortality. In yetanother non-limiting example, machine-learning models may examinetelomeric DNA length and subsequent diagnosis of diseases such ascardiovascular disease, diabetes, leukemia and the like.Machine-learning models may examine correlations and relationshipsbetween physiological state and severity and/or how rapidly a diseaseprogresses such as pancreatic cancer. Machine-learning models mayexamine factors such as age of onset and how rapidly a diseaseprogresses such as neurological diseases including for exampleAlzheimer's disease, Parkinson's disease, Bell's palsy, Lupus, stroke,rheumatoid arthritis, multiple sclerosis and the like. Prognostic labellearner 152 may generate prognostic output from prognostic label as afunction of the first training data set and at least a biologicalextraction. This may be done by any of the methodologies as describedabove. Prognostic output may be generated as a function of aclassification of prognostic label. This may be done by any of themethodologies as described above.

With continued reference to FIG. 19, diagnostic engine 108 generates atleast a diagnostic output include at least an ameliorative processlabel. Ameliorative process label may be generated by ameliorative labellearner 140 operating on diagnostic engine 108. Ameliorative processlabel may be generated as a function of the second training set and atleast a prognostic output. Ameliorative process label may be generatedby a lazy learning as a function of the second training set and at leastan ameliorative process descriptor.

With continued reference to FIG. 19, ameliorative process label learnergenerates the at least an ameliorative output by creating asecond-machine learning model using the second training set relatingprognostic labels to ameliorative labels. Second machine-learning modelmay use ameliorative label to generate at least an ameliorative output.Ameliorative output may be generated as a function of a classificationof the at least a prognostic output. Prognostic output may be classifiedby any schematic as described above in reference to FIGS. 1-18. Secondmachine learning-model may use models to create correlations relating aprognostic output such as osteoarthritis to an ameliorative label withan exercise recommendation that includes walking, swimming and/or bikingso as to be easy on the joints. In yet another example, machine-learningmodels may create correlations relating a prognostic output such ascoronary artery occlusion to an ameliorative label such as angioplasty.Machine-learning models may group certain prognostic outputs to generateameliorative labels. For example, prognostic outputs that includedisease states associated with impaired fasting blood sugar such asdiabetes, polycystic ovarian syndrome, cardiovascular disease, metabolicsyndrome, and the like may be linked to an ameliorative label thatincludes an aerobic exercise regimen. In yet another non-limitingexample, prognostic outputs that indicate a risk factor forcardiovascular disease such as uncontrolled hypertension, physicalinactivity, obesity, uncontrolled diabetes, congenital heart disease,family history of heart disease, positive smoking status, highcholesterol, high triglycerides, low HDL, and the like may be linked toan ameliorative label that includes a recommendation to check 25-hydroxyvitamin D blood test. In yet another non-limiting example,machine-learning models may be utilized so that a prognostic output thatis indicative of early aging such as short telomer length may be linkedto an ameliorative label that includes anti-aging supplementation suchas bioidentical hormone replacement therapy, pregnenolonesupplementation, resveratrol supplementation, coenzyme q10supplementation and the like. Machine-learning models may be utilized sothat an ameliorative label may be linked to a prognostic output thatincludes a future risk of developing a disease or condition. Forexample, a prognostic output that includes a positive BRCA1 diagnosismay be associated with an ameliorative label that includes dietaryrecommendations containing high consumption of cruciferous vegetables.In yet another non-limiting example, a prognostic output that includes apositive presence of commensal C. difficile may be associated with anameliorative label that includes recommendations to supplement withSaccharomyces Boulardii. Ameliorative output may be generated as afunction of the second training data set and the at least a prognosticoutput. This may be performed by any of the methodologies as describedabove. Ameliorative output may be generated a function of aclassification of the at least a prognostic output. This may beperformed by any of the methodologies as described above.

With continued reference to FIG. 19, at step 1920 diagnostic engine 108transmits the diagnostic output including at least a prognostic outputand at least an ameliorative output to at least an advisor clientdevice. Transmission may be implemented for example, as described abovein reference to FIG. 1.

With continued reference to FIG. 19, at step 1925 at least an advisorymodule 184 operating on the at least a server 104 generates at least anadvisory output as a function of the diagnostic output. Advisory module184 may receive at least an informed advisor input. Generating at leastan advisory output as a function of the diagnostic output may includeevaluating at least an informed advisor input. Language processingmodule 128 may evaluate at least an informed advisor input and extractone or more words. In an embodiment, diagnostic engine 108 may transmitat least an output to an advisor client device. Informed advisor such asa functional medicine doctor may evaluate the at least an output and mayprovide feedback. Feedback could include evaluation of diagnostic outputgenerated by diagnostic engine 108. For example, diagnostic engine 108may generate an output that contains 3 possible diagnoses includingchicken pox, contact dermatitis, and an immunoglobulin E (IgE) mediatedmaculopapular rash to a food allergen, for a user complaining of anitchy red rash. Upon receiving diagnostic output from diagnostic engine108 at advisor client device 132, functional medicine doctor may have anin-person and/or electronic meeting with user whereby functionalmedicine doctor can perform a physical examination and view user's rash.Functional medicine doctor may be able to eliminate possible diagnosesusing functional medicine doctor's medical knowledge and experience, andupon viewing using, and may generate at least an advisory inputindicating such input. In such an instance, language processing module128 may evaluate functional medicine doctor's input and may examineinput for key words or phrases such as for example “diagnosis isconfirmed to chicken pox” or “user is not diagnosed with contactdermatitis.” Such information may then be utilized by advisory module184 to generate at least an advisory output.

Continuing to view FIG. 19, advisory module 184 may generate advisoryoutput containing textual elements that may allow an informed advisor toanalyze advisory output based on information that is pertinent toinformed advisor. Advisory output may include for example specializedinstruction set 1504, textual entry field 1512, category field 1516,and/or relevance field 1520 as described in more detail above inreference to FIG. 15. Any of the textual fields as listed above may begenerated to allow an informed advisor to search and/or browse through alarge quantity of data relatively quickly to find an item of interest.Textual fields may allow for example an informed advisor to browse to atable of contents to find pertinent information such as a certain testresult or results from a procedure that were obtained as described inmore detail above in FIG. 15. Textual fields may allow an informedadvisor to have an advisory output open to most relevant results, suchas a cardiologist who may be interested in relevant results such ascholesterol measurements and fasting glucose levels. Textual fields mayallow an informed advisor to generate an advisory output to anotherinformed advisor containing information of relevance. For example, afunctional medicine doctor may share relevant information surrounding auser's mental health with friends and family for a user suffering withdepression. This may include information such as a user's response to amedication and/or supplement to treat user's depression. Textual fieldsmay be implemented and may include any of the textual fields asdescribed above in reference to FIG. 15.

With continued reference to FIG. 19, at step 1930 at least an advisorymodule 184 operating on the at least a server 104 transmits the at leastan advisory output to at least an advisor client device. Transmissionmay be implemented for example, as described above in reference to FIG.1.

With continued reference to FIG. 19, a plan generator module 168operating on the at least a server 104 may generate a comprehensiveinstruction set associated with a user as a function of the diagnosticoutput at the at least an advisory output. For instance and withoutlimitation, generating comprehensive instruction set 172 may includedetermining that a first prognostic label of the at least a prognosticlabel and a second prognostic label of the at least a prognostic labelbelong to a shared category and adding a category label associated withthe shared category to the comprehensive instruction set 172. As anadditional example, generating the comprehensive instruction set 172 mayinclude determining a first ameliorative label of the at least anameliorative label is a duplicate of a second ameliorative label of theat least an ameliorative label, and eliminating the first prognosticlabel. As an additional example, generating comprehensive instructionset 172 may include determining that a first ameliorative label of theat least an ameliorative label and a second ameliorative label of the atleast an ameliorative label belong to a shared category and adding acategory label associated with the shared category to the comprehensiveinstruction set 172. Generating comprehensive instruction set 172 mayinclude, as a further example, receiving at least an element of userdata and filtering the diagnostic output using the at least an elementof user data. Comprehensive instruction set 172 may be transmitted touser client device 180.

It is to be noted that any one or more of the aspects and embodimentsdescribed herein may be conveniently implemented using one or moremachines (e.g., one or more computing devices that are utilized as auser computing device for an electronic document, one or more serverdevices, such as a document server, etc.) programmed according to theteachings of the present specification, as will be apparent to those ofordinary skill in the computer art. Appropriate software coding canreadily be prepared by skilled programmers based on the teachings of thepresent disclosure, as will be apparent to those of ordinary skill inthe software art. Aspects and implementations discussed above employingsoftware and/or software modules may also include appropriate hardwarefor assisting in the implementation of the machine executableinstructions of the software and/or software module.

Such software may be a computer program product that employs amachine-readable storage medium. A machine-readable storage medium maybe any medium that is capable of storing and/or encoding a sequence ofinstructions for execution by a machine (e.g., a computing device) andthat causes the machine to perform any one of the methodologies and/orembodiments described herein. Examples of a machine-readable storagemedium include, but are not limited to, a magnetic disk, an optical disc(e.g., CD, CD-R, DVD, DVD-R, etc.), a magneto-optical disk, a read-onlymemory “ROM” device, a random access memory “RAM” device, a magneticcard, an optical card, a solid-state memory device, an EPROM, an EEPROM,and any combinations thereof. A machine-readable medium, as used herein,is intended to include a single medium as well as a collection ofphysically separate media, such as, for example, a collection of compactdiscs or one or more hard disk drives in combination with a computermemory. As used herein, a machine-readable storage medium does notinclude transitory forms of signal transmission.

Such software may also include information (e.g., data) carried as adata signal on a data carrier, such as a carrier wave. For example,machine-executable information may be included as a data-carrying signalembodied in a data carrier in which the signal encodes a sequence ofinstruction, or portion thereof, for execution by a machine (e.g., acomputing device) and any related information (e.g., data structures anddata) that causes the machine to perform any one of the methodologiesand/or embodiments described herein.

Examples of a computing device include, but are not limited to, anelectronic book reading device, a computer workstation, a terminalcomputer, a server computer, a handheld device (e.g., a tablet computer,a smartphone, etc.), a web appliance, a network router, a networkswitch, a network bridge, any machine capable of executing a sequence ofinstructions that specify an action to be taken by that machine, and anycombinations thereof. In one example, a computing device may includeand/or be included in a kiosk.

FIG. 20 shows a diagrammatic representation of one embodiment of acomputing device in the exemplary form of a computer system 2000 withinwhich a set of instructions for causing a control system to perform anyone or more of the aspects and/or methodologies of the presentdisclosure may be executed. It is also contemplated that multiplecomputing devices may be utilized to implement a specially configuredset of instructions for causing one or more of the devices to performany one or more of the aspects and/or methodologies of the presentdisclosure. Computer system 2000 includes a processor 2004 and a memory2008 that communicate with each other, and with other components, via abus 2012. Bus 2012 may include any of several types of bus structuresincluding, but not limited to, a memory bus, a memory controller, aperipheral bus, a local bus, and any combinations thereof, using any ofa variety of bus architectures.

Memory 2008 may include various components (e.g., machine-readablemedia) including, but not limited to, a random-access memory component,a read only component, and any combinations thereof. In one example, abasic input/output system 2016 (BIOS), including basic routines thathelp to transfer information between elements within computer system2000, such as during start-up, may be stored in memory 2008. Memory 2008may also include (e.g., stored on one or more machine-readable media)instructions (e.g., software) 2020 embodying any one or more of theaspects and/or methodologies of the present disclosure. In anotherexample, memory 2008 may further include any number of program modulesincluding, but not limited to, an operating system, one or moreapplication programs, other program modules, program data, and anycombinations thereof.

Computer system 2000 may also include a storage device 2024. Examples ofa storage device (e.g., storage device 2024) include, but are notlimited to, a hard disk drive, a magnetic disk drive, an optical discdrive in combination with an optical medium, a solid-state memorydevice, and any combinations thereof. Storage device 2024 may beconnected to bus 2012 by an appropriate interface (not shown). Exampleinterfaces include, but are not limited to, SCSI, advanced technologyattachment (ATA), serial ATA, universal serial bus (USB), IEEE 1394(FIREWIRE), and any combinations thereof. In one example, storage device2024 (or one or more components thereof) may be removably interfacedwith computer system 2000 (e.g., via an external port connector (notshown)). Particularly, storage device 2024 and an associatedmachine-readable medium 2028 may provide nonvolatile and/or volatilestorage of machine-readable instructions, data structures, programmodules, and/or other data for computer system 2000. In one example,software 2020 may reside, completely or partially, withinmachine-readable medium 2028. In another example, software 2020 mayreside, completely or partially, within processor 2004.

Computer system 2000 may also include an input device 2032. In oneexample, a user of computer system 2000 may enter commands and/or otherinformation into computer system 2000 via input device 2032. Examples ofan input device 2032 include, but are not limited to, an alpha-numericinput device (e.g., a keyboard), a pointing device, a joystick, agamepad, an audio input device (e.g., a microphone, a voice responsesystem, etc.), a cursor control device (e.g., a mouse), a touchpad, anoptical scanner, a video capture device (e.g., a still camera, a videocamera), a touchscreen, and any combinations thereof. Input device 2032may be interfaced to bus 2012 via any of a variety of interfaces (notshown) including, but not limited to, a serial interface, a parallelinterface, a game port, a USB interface, a FIREWIRE interface, a directinterface to bus 2012, and any combinations thereof. Input device 2032may include a touch screen interface that may be a part of or separatefrom display 2036, discussed further below. Input device 2032 may beutilized as a user selection device for selecting one or more graphicalrepresentations in a graphical interface as described above.

A user may also input commands and/or other information to computersystem 2000 via storage device 2024 (e.g., a removable disk drive, aflash drive, etc.) and/or network interface device 2040. A networkinterface device, such as network interface device 2040, may be utilizedfor connecting computer system 2000 to one or more of a variety ofnetworks, such as network 2044, and one or more remote devices 2048connected thereto. Examples of a network interface device include, butare not limited to, a network interface card (e.g., a mobile networkinterface card, a LAN card), a modem, and any combination thereof.Examples of a network include, but are not limited to, a wide areanetwork (e.g., the Internet, an enterprise network), a local areanetwork (e.g., a network associated with an office, a building, a campusor other relatively small geographic space), a telephone network, a datanetwork associated with a telephone/voice provider (e.g., a mobilecommunications provider data and/or voice network), a direct connectionbetween two computing devices, and any combinations thereof. A network,such as network 2044, may employ a wired and/or a wireless mode ofcommunication. In general, any network topology may be used. Information(e.g., data, software 2020, etc.) may be communicated to and/or fromcomputer system 2000 via network interface device 2040.

Computer system 2000 may further include a video display adapter 2052for communicating a displayable image to a display device, such asdisplay device 2036. Examples of a display device include, but are notlimited to, a liquid crystal display (LCD), a cathode ray tube (CRT), aplasma display, a light emitting diode (LED) display, and anycombinations thereof. Display adapter 2052 and display device 2036 maybe utilized in combination with processor 2004 to provide graphicalrepresentations of aspects of the present disclosure. In addition to adisplay device, computer system 2000 may include one or more otherperipheral output devices including, but not limited to, an audiospeaker, a printer, and any combinations thereof. Such peripheral outputdevices may be connected to bus 2012 via a peripheral interface 2056.Examples of a peripheral interface include, but are not limited to, aserial port, a USB connection, a FIREWIRE connection, a parallelconnection, and any combinations thereof.

The foregoing has been a detailed description of illustrativeembodiments of the invention. Various modifications and additions can bemade without departing from the spirit and scope of this invention.Features of each of the various embodiments described above may becombined with features of other described embodiments as appropriate inorder to provide a multiplicity of feature combinations in associatednew embodiments. Furthermore, while the foregoing describes a number ofseparate embodiments, what has been described herein is merelyillustrative of the application of the principles of the presentinvention. Additionally, although particular methods herein may beillustrated and/or described as being performed in a specific order, theordering is highly variable within ordinary skill to achieve methods,systems, and software according to the present disclosure. Accordingly,this description is meant to be taken only by way of example, and not tootherwise limit the scope of this invention.

Exemplary embodiments have been disclosed above and illustrated in theaccompanying drawings. It will be understood by those skilled in the artthat various changes, omissions and additions may be made to that whichis specifically disclosed herein without departing from the spirit andscope of the present invention.

What is claimed is:
 1. A system for utilizing diagnostics for informedvibrant constitutional guidance, the system comprising: at least aserver; a diagnostic engine operating on the at least a server, whereinthe diagnostic engine is configured to: generate a machine learningmodel, wherein the machine-learning model comprises a trainedmachine-learning model trained by a training data set; wherein themachine-learning model is configured to receive contextual informationas an input and output a diagnostic output; and wherein the trainingdata set includes a plurality of data entries, each data entry of theplurality of data entries including at least an element of contextualinformation and at least a correlated diagnostic output; and at least anadvisory module, operating on the at least a server, the at least anadvisory module designed and configured to: generate an advisory outputas a function of the diagnostic output, wherein the advisory outputcomprises textual data identifying the diagnostic output and wherein thetextual data identifying the diagnostic output is configured to bedisplayed on an advisor client device; and transmit the advisory outputto the advisor client device.
 2. The system of claim 1, wherein the atleast an element of contextual information includes a patient medicalhistory.
 3. The system of claim 1, wherein the at least an element ofcontextual information includes a patient goal.
 4. The system of claim1, wherein the at least an element of contextual information includes apatient question.
 5. The system of claim 1, wherein the at least anelement of contextual information includes a treatment plan status. 6.The system of claim 1, further comprising a plan generator module,operating on the at least a server, wherein the plan generator module isconfigured to generate a comprehensive instruction set associated to thediagnostic output.
 7. The system of claim 6, wherein the comprehensiveinstruction set includes a future prognostic status.
 8. The system ofclaim 6, wherein the plan generator module is further configured toproduce at least a current prognostic descriptor.
 9. The system of claim6, wherein the plan generator module includes a label synthesizer. 10.The system of claim 6, wherein the plan generator module is furtherconfigured to: receive at least an element of user data; and filter thediagnostic output using the at least an element of user data.
 11. Amethod of utilizing diagnostics for informed vibrant constitutionalguidance the method comprising: generating, by at least a server, amachine-learning model, wherein the machine-learning model comprises atrained machine-learning model trained by a training data set; whereinthe machine-learning model is configured to receive contextualinformation as an input and output a diagnostic output; wherein thetraining data set includes a plurality of data entries, each data entryof the plurality of data entries including at least an element ofcontextual information and at least a correlated diagnostic output;generating, by the at least a server, an advisory output as a functionof the diagnostic output, wherein the advisory output comprises textualdata identifying the diagnostic output and wherein the textual dataidentifying the diagnostic output is configured to be displayed on anadvisor client device; and transmitting, by the at least a server, theadvisory output to the advisor client device.
 12. The method of claim11, wherein contextual information includes patient medical history. 13.The method of claim 11, wherein contextual information includes apatient goal.
 14. The method of claim 11, wherein contextual informationincludes a patient question.
 15. The method of claim 11, whereincontextual information includes a treatment plan status.
 16. The methodof claim 11, further comprising generating, by the at least a server, acomprehensive instruction set associated to the diagnostic output as afunction of a plan generator module.
 17. The method of claim 16, whereinthe comprehensive instruction set includes a future prognostic status.18. The method of claim 16, wherein the plan generator module includes alabel synthesizer.
 19. The method of claim 11, further comprisingproducing, by the at least a server, at least a current prognosticdescriptor.
 20. The method of claim 11, further comprising: receiving,by the at least a server, at least an element of user data; andfiltering, by the at least a server, the diagnostic output using the atleast an element of user data.